Wave-guide coupling surface plasma resonance biosensor

A technology of surface plasmon and plasmon resonance, applied in the field of biosensors, can solve the problem of narrow wavelength range of adjustable laser

Active Publication Date: 2007-05-30
IND TECH RES INST
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Problems solved by technology

This technology uses adjustable diode laser and lock-in amplification technology to achieve a lower measurement limit to detect trace biomolecules. However, due to the narrow wavelength range of the

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  • Wave-guide coupling surface plasma resonance biosensor
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  • Wave-guide coupling surface plasma resonance biosensor

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Embodiment Construction

[0046] The phenomenon of waveguide coupling surface plasmon resonance is that when parallel white light or monochromatic light with different incident angles is irradiated, only a narrow wavelength or a specific angle excites surface plasmons to generate a reflection absorption spectrum, and its central wavelength or angle is called waveguide coupling. Surface plasmon resonance wavelength or angle. When the waveguide-coupled surface plasmon resonance structure is slightly damaged, such as the adsorption of biomolecules on the surface causes a slight change in the refractive index or thickness, the light wave vector that couples the excited surface plasmons changes, causing the resonance wavelength or angle to drift . Therefore, the interaction between biomolecules can be dynamically detected in real time without any label. The waveguide-coupled surface plasmon resonance structure with a sub-wavelength metal grating structure can increase the sensitivity of the biosensor by mo...

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Abstract

A waveguide coupling surface plasma resonance biosensor is disclosed that includes: a grating layer, a waveguide layer, a plasma resonance layer and a ligand layer. The grating layer which has a periodical first grating structure is made of translucent material, the waveguide layer is formed on the first grating structure, and the refractive index of the waveguide layer is bigger than the refractive index of the grating layer. The plasma resonance is formed on the waveguide layer which can generate plasma resonance by means of light wave excitation. The ligand layer is formed on the plasma resonance layer, and the ligand layer can generate combination reaction with the detecting substance. The analytical platform of molecular interaction can be built using the invention, and a detecting method without marking can detect the physical quantities of molecular interaction of chemical material, reaction rate and molecular dynamics.

Description

technical field [0001] The present invention relates to a biosensor, in particular to a waveguide-coupled surface plasmon resonance biosensor that uses gratings and metal materials to establish an interaction analysis platform for biomolecules that does not require any labeling procedures to measure the physical quantities of intermolecular interactions in real time. . Background technique [0002] In biomolecular interaction analysis (BIA), the development and application of biochips is one of the key technologies for modern biotechnology to move from genomics to proteomics. Biochips are useful tools for simultaneously detecting a large number of gene expressions or detecting trace amounts of biomolecular information. Today's detection is still dominated by fluorescence detection. However, the fluorescent system involves cumbersome fluorescent labeling, the difficulty of some molecular labeling, the inevitable fluorescence decay, and the difficulty of providing real-time k...

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Application Information

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IPC IPC(8): G01N33/00G01N21/00
Inventor 陈显祯毛彦杰易政男简汎清林俊佑朱怡铭陈来胜王维汉吴兆棋林彦君
Owner IND TECH RES INST
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