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Medicinal preparation for treating immune related diseases

A correlation and disease-related technology, applied in the field of medicine and health, can solve problems such as poor repeatability, inconsistent curative effect, and unstable results, and achieve the effects of improving prognosis, reducing the number of blood transfusions, and reducing treatment costs

Inactive Publication Date: 2007-06-20
朱宏丽 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the curative effect is different, the results are unstable, and the reproducibility is poor

Method used

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  • Medicinal preparation for treating immune related diseases

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Effect test

Embodiment 1

[0029] Embodiment 1: Clinical trial of the pharmaceutical preparation of the present invention in treating myelodysplastic syndrome (MDS).

[0030] 1. Case information

[0031]Among the 12 patients, 11 were males and 1 female, with a median age of 83 (19-91) years. The diagnosis of MDS in patients mainly depends on peripheral blood, bone marrow and chromosome examination. Among them, there were 5 cases of MDS-RA, 2 cases of MDS-RAS, and 5 cases of MDS-RCMD. Before this treatment, all patients had received hematopoietic stimulating factors, large doses of vitamin B6, androgen, hormones, immunosuppressants, blood transfusion and other treatments. Relying on blood transfusion (1 time / 2 weeks) causes excessive iron load in the body and affects organ function. The general conditions of the 12 patients are shown in Table 1.

[0032] Table 1 General condition of patients

[0033] Numbering

age

gender

(M / F)

disease

course of treatment ...

Embodiment 2

[0046] Embodiment 2: Clinical trial of the pharmaceutical preparation of the present invention in treating idiopathic thrombocytopenic purpura (ITP).

[0047] 1. Case information

[0048] The 3 patients were all elderly men. 2 patients had been diagnosed with ITP in the past and improved after hormone therapy. This time, there was no obvious cause for bleeding signs (bleeding spots, gingival bleeding, and epistaxis); 1 patient had systemic bleeding spots and epistaxis after a cold. ecchymosis. It was found that the platelet counts of all patients were far lower than normal (4-17)×109 / L, and the bone marrow examination showed active proliferation but impaired megakaryocyte maturation. According to medical history, signs and various examinations, 3 patients were diagnosed with idiopathic thrombocytopenic purpura. Two cases received hormone therapy after admission, and the platelet level increased. One case reached the normal level within 2 weeks, and the other fluctuated betwe...

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Abstract

A medicine for treating the immune associated diseases including immune associated hematopathy, such as myeloproliferative syndrome, simple anerythroregenerative anemia, aplastic anemia, primary thrombopenic purpura, etc, contains sodium bicarbonate and ethiophosphate.

Description

technical field [0001] The invention belongs to the therapeutic part of clinical internal medicine in the field of medicine and health, and specifically relates to a pharmaceutical preparation for treating immune-related diseases. Background technique [0002] Immune-related diseases include many types of diseases, almost involving the seven major systems of the body, including breathing, digestion, circulation, blood, endocrine, skin, and bone and joints. However, current treatments have limited efficacy and serious adverse reactions. [0003] The existing treatment of immune-related diseases is mainly based on glucocorticoids and non-steroidal anti-inflammatory drugs, and sometimes chemotherapy drugs are used to achieve curative effect, such as methotrexate, cyclophosphamide, etc. The principle is mainly to suppress (hormones) or destroy (chemotherapy) the body's immune system to function, or to suppress (non-steroidal anti-inflammatory drugs) the inflammation that occurs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/661A61K33/10A61K9/08A61P35/00A61P37/02
Inventor 朱宏丽李晓峰卢学春
Owner 朱宏丽
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