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Agents for preventing and treating HIV and other viral infections

a technology for viral infections and agents, applied in the field of agents for preventing and treating hiv and other viral infections, can solve the problems of high frequency of infections, inability to cure the disease, physical and mental stress resulting from the permanent need to take drugs, etc., and achieve the effect of reducing the infection efficiency of hiv and preventing the development of hiv-associated bacteria

Active Publication Date: 2018-07-24
PRIAVOID GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The agents significantly reduce HIV infectivity by up to 95% by preventing or destroying amyloid fibrils, thereby slowing disease progression and preventing neurological damage, with no side effects on vital cells or DNA polymerase, effectively addressing the limitations of existing treatments.

Problems solved by technology

With the exception of one isolated case that has been described, the disease is not curable as of yet and requires lifelong treatment, which suppresses the infection-related symptoms by inhibiting HIV replication.
The therapy, however, must be conducted for life since the viral infection is generally only suppressed, but not cured.
The physical and mental stress resulting from the permanent need to take drugs and from an increased frequency of infections is high, as are the costs of years of HAART.
While HAART lowers the risk of infection for HIV due to a reduced viral load, an infection cannot be avoided.
Development has not yet progressed greatly.

Method used

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  • Agents for preventing and treating HIV and other viral infections
  • Agents for preventing and treating HIV and other viral infections
  • Agents for preventing and treating HIV and other viral infections

Examples

Experimental program
Comparison scheme
Effect test

exemplary embodiment 1

ic Inhibitor D3 for Reducing the SEVI- or Aβ-Mediated Viral Infection

[0109]So as to analyze the effect of the amyloidogenic inhibitor D3 as a potential therapeutic agent for reducing amyloid peptide-promoted retroviral propagation, adherently growing TZM-bl cells were infected with HIV-1. These cells express the HIV-1 receptors CD4, CXCR4 and CCR5, which is why they are permissive both for T-tropic and M-tropic HIV isolates. Furthermore, they express the reporter genes β-galactosidase and luciferase under the control of the HIV-1 LTR promoter, the expression of which can thus be induced by an HIV-1 infection and consequently demonstrated. The TZM-bl indicator cell line thus allows a quantitative analysis of HIV infection efficiency.

[0110]TZM-bl cells were infected with equal amounts of HIV-1, which had previously been incubated with different concentrations of Aβ1-42 fibrils, which, in turn, had been treated with two concentrations of the peptide D3 or PBS as solvent control. D3 was...

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Abstract

An agent for preventing and / or treating HIV and other viral infections. The agent in particular comprises at least one peptide, including an amino acid sequence, which is suitable for preventing fibrils associated with Alzheimer's disease, and / or homologs, fractions and parts thereof, so as to treat and / or prevent HIV and / or other viral infections.

Description

[0001]The invention relates to agents for preventing and treating HIV and other viral infections.BACKGROUND OF THE INVENTION[0002]The human immunodeficiency virus, HIV for short, belongs to the retrovirus family and to the lentivirus genus. An HIV infection when left untreated generally results in acquired immunodeficiency syndrome (AIDS) following a variably long incubation period, which typically takes several years. Over the past 30 years, the spread of HIV has evolved into a pandemic, which according to estimates of the UNAIDS organization has cost some 28 million lives so far. At the end of 2010, an estimated 34 million people worldwide were infected with HIV. With the exception of one isolated case that has been described, the disease is not curable as of yet and requires lifelong treatment, which suppresses the infection-related symptoms by inhibiting HIV replication.[0003]According to the German-Austrian guidelines for antiretroviral therapy of HIV infection, the goal of ant...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): C07K14/47A61K38/16A61K9/06A61K9/00A61K9/20A61K38/12A61K38/10C07K7/08A61K38/00
CPCC07K14/47A61K9/0019A61K9/06A61K9/20A61K38/12A61K38/16C07K7/08C07K14/4711A61K38/10A61K38/00A61P25/28A61P31/18
Inventor FUNKE, SUSANNE AILEENWILLBOLD, DIETERSCHAAL, HEINERWIDERA, MAREK
Owner PRIAVOID GMBH