Transgenic zebra fish embryo model for hematopoiesis and lymphoproliferative disorders
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- PARKER HUGHES INST
- Publication Date
- 2005-09-08
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Abstract
Description
BACKGROUND OF THE INVENTION
[0001] Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children (Pizzo and Poplack, 1993, Greaves, 1986, Uckun et al., 1998, Crist et al., 1988). A better understanding of the biological basis and predisposing leukemogenic events in this disease is needed in order to develop more effective treatment programs as well as novel prevention strategies.
[0002] Leukemic clones are thought to originate in ALL patients from normal lymphocyte precursors arrested at various stages of T- or B-lymphocyte development (Greaves, 1986). Accordingly, any critical regulatory network that controls normal lymphocyte development is a potential target for a leukemogenic event.
[0003] One such regulatory network vital for normal hematopoiesis involves Ikaros, a member of the Kruppel family “zinc finger” DNA-binding proteins. Ikaros acts as an evolutionarily conserved “master switch” of hematopoiesis that dictates the transcriptional regulation of lymphocy...