Transgenic circulating endothelial cells

a technology of circulating endothelial cells and circulating endothelial cells, which is applied in the direction of cell culture active agents, packaged goods types, peptide/protein ingredients, etc., can solve the problems of inaccessibility of vascular endothelial cells in the research field, and achieve the effect of improving the permeability of the vascular endothelial cells
US20060013805A1Inactive Publication Date: 2006-01-19RGT UNIV OF MINNESOTA +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
RGT UNIV OF MINNESOTA
Publication Date
2006-01-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected bioactive polypeptide. The resulting transgenic endothelial cells are useful to biocompatibilize implantable medical devices or can be used directly, as for gene therapy.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional application of U.S. application Ser. No. 09 / 865,022, filed May 24, 2001, which is a national stage filing of PCT / US99 / 28033, filed Nov. 24, 1999, which claims the benefit of the filing date of U.S. application Ser. No. 60 / 109,687, filed Nov. 24, 1998, the disclosures of which are incorporated by reference herein.BACKGROUND OF THE INVENTION

[0002] The endothelial cell participates in numerous functions of vascular physiology. Many factors, such as cytokines, can alter the surface of the endothelial cell and thereby modulate the role of the endothelium in coagulation, inflammation, vaso-regulation, and adhesion. See, for example, R. P. Hebbel et al., J. Lab. Clin. Med., 129, 288 (1997); J. S. Pober, Am. J. Path., 133, 426 (1988); E. J. Favaloro, Immunol. Cell. Biol., 71, 571 (1993). The endothelial cell may also have a key role in the vascular pathology of sickle cell anemia, including the vaso-occlusions ...

Claims

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