Nitrogen-containing cyclic compound and pharmaceutical composition containing the compound

Abstract

The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C3-14 hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula —CO—, etc.; X indicates a single bond, an oxygen atom etc.; R1 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D1, D2, W1 and W2 are the same as or different from each other and each represents a single bond or an optionally substituted C1-6 alkylene chain.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a Divisional of co-pending U.S. application Ser. No. 10 / 855,357 filed on May 28, 2004, which is a Divisional of U.S. application Ser. No. 10 / 169,837 filed Jul. 10, 2002, and for which priority is claimed under 35 U.S.C. § 120; U.S. application Ser. No. 10 / 169,837 is the National Phase of International Application No. PCT / JP01 / 00288 having an international filing date of Jan. 18, 2001, which claims priority of Application No. 2000-12176 filed in Japan on Jan. 20, 2000 under 35 U.S.C. § 119; the entire contents of all above are hereby incorporated by reference.TECHNICAL FIELD [0002] The present invention relates to a novel compound useful as a calcium antagonist, a salt thereof, a hydrate of them, a production process thereof, and a pharmaceutical composition thereof; and specifically relates to a neuron-selective calcium antagonist, in particular a novel compound having a P / Q-type calcium channel and / or an N-type calc...

AI Technical Summary

Benefits of technology

[0020] In light of this, the present inventors have intensively studied for investigating a preparation which has a superior effect of treatment and amelioration for cerebral acute ischemic stroke for which no useful preparation is not found and has high safety which does not cause bloodshed tendency, focusing on a neuron-selective, potential-dependent calcium channel antagonist which directly effects on neural cell and inhibits the progression of infarction nidus. As a result, the present inventors have succeeded in synthesizing a novel nitrogen-containing compound which is represented by the formula (I), a salt thereof and a hydrate thereof, and further surprisingly have found that these compounds, a salt thereof or a hydrate thereof have the superior suppression action of neural cell death and protective action of cerebral neuron based on the P / Q type or N-type calcium channel antagonism, that cell infarction property and toxicity are remarkably reduced in comparison with a conventional calcium antagonist and that the compound and the like are superior in safety, and have completed the present invention.

Problems solved by technology

However, the therapy according to a conventional medicine is the complicate procedures as described in (1) to (6), and cautious judgment by a specialist on the basis of enough knowledge and experience has been required.

However, argatroban is not applicable to lacuna infarction.

Further, the therapeutic effects of the drugs used heretofore are not satisfactory and further there is the danger that bleeding is often accompanied by their pharmacological effect.

Accordingly, there is the problem that it is difficult for those except of skilled medical specialists to use these drugs.

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