Renal progenitor cells from embryonic stem cells

US20070031966A1Inactive Publication Date: 2007-02-08RGT UNIV OF MICHIGAN
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
RGT UNIV OF MICHIGAN
Publication Date
2007-02-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to compositions and methods for inducing the differentiation of stem cells into renal progenitor cells. In particular, the present invention provides compositions containing activin-a, retinoic acid, and bmp-7, and variants thereof, for differentiating stem cells into renal cells containing tubular epithelia. In certain embodiments, the present invention provides stem cells cultured with compositions used to treat renal disease.
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Description

[0001] This application claims priority to U.S. Provisional Application Ser. No. 60 / 700,234, filed Jul. 18, 2005, which is herein incorporated by reference in its entirety.

[0002] The present application was funded in part with government support under grant number DK069689 from the National Institutes of Health. The government may have certain rights in this invention.FIELD OF THE INVENTION

[0003] The present invention relates to compositions and methods for inducing the differentiation of stem cells into renal progenitor cells. In particular, the present invention provides compositions containing activin-a, retinoic acid, and bmp-7, and variants thereof, for differentiating stem cells into renal cells containing tubular epithelia. In certain embodiments, the present invention provides stem cells cultured with compositions used to treat renal disease. BACKGROUND OF THE INVENTION

[0004] Kidney disease is a major health problem in the United States, afflicting some eight million Ameri...

Claims

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