Isoindole-imide compounds and compositions comprising and methods of using the same

a technology of isoindoleimide and compounds, applied in the field of isoindoleimide compounds, can solve the problems of limited treatment options, significant drawbacks for patients, and few treatment options for cancer treatmen

Inactive Publication Date: 2007-03-01
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0016] This invention also encompasses methods of treating and managing various diseases or disorders. The methods comprise administering to a patient in need of such treatment or management a therapeutically effective amount of a compound of this invention, or a pharmaceutically acceptable salt, solvate, stereoisomer, or pro...

Problems solved by technology

However, options for the treatment of cancer are limited.
For example, in the case of blood cancers (e.g., multiple myeloma), few treatment options are available, especially when conventional chemotherapy fails and bone-marrow transplantation is not an option.
All of these approaches pose significant drawbacks for the patient.
Surgery, for example, may be contraindicated due to the health of a patient or may be unacceptable to the patient.
Additionally, surgery may not completely remove neoplastic tissue.
Radiation therapy is only effective when the neoplastic tissue exhibits a higher sensitivity to radiation than normal tissue.
Radiation therapy can also often elicit serious side effects.
Biological therapies an...

Method used

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  • Isoindole-imide compounds and compositions comprising and methods of using the same
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  • Isoindole-imide compounds and compositions comprising and methods of using the same

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Embodiment Construction

[0019] In one embodiment, this invention encompasses isoindole-imide compounds, and pharmaceutically acceptable salts, solvates, stereoisomers and prodrugs thereof. In another embodiment, this invention encompasses methods of treating, managing, and preventing various diseases and disorders, which comprises administering to a patient in need of such treatment or prevention a therapeutically or prophylactically effective amount of a compound of this invention, or a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof. Examples of diseases and disorders are described herein.

[0020] In particular embodiments, a compound of this invention, or a pharmaceutically acceptable salt, solvate, stereoisomer, or prodrug thereof, is administered in combination with another drug (“second active agent”) or treatment. Second active agents include small molecules and large molecules (e.g., proteins and antibodies), examples of which are provided herein, as well as stem cells. Me...

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Abstract

This invention relates to isoindole-imide compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Description

[0001] This application claims priority to U.S. provisional No. 60 / 712,387, filed Aug. 31, 2005, the entirety of which is incorporated herein by reference.1. FIELD OF THE INVENTION [0002] This invention relates to isoindole-imide compounds. Pharmaceutical compositions comprising the compounds and methods for treating, preventing and managing various disorders are also disclosed. 2. BACKGROUND OF THE INVENTION [0003] 2.1 Pathobiology of Cancer and Other Diseases [0004] Cancer is characterized primarily by an increase in the number of abnormal cells derived from a given normal tissue, invasion of adjacent tissues by these abnormal cells, or lymphatic or blood-borne spread of malignant cells to regional lymph nodes and to distant sites (metastasis). Clinical data and molecular biologic studies indicate that cancer is a multistep process that begins with minor preneoplastic changes, which may under certain conditions progress to neoplasia. The neoplastic lesion may evolve clonally and d...

Claims

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Application Information

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IPC IPC(8): A61K31/454C07D403/04
CPCC07D401/04C07D401/14C07D405/14C07D409/14C07D413/14C07D417/14A61P11/00A61P17/00A61P19/02A61P25/00A61P25/04A61P25/20A61P25/28A61P27/02A61P29/00A61P31/00A61P33/00A61P35/00A61P37/02A61P43/00A61P7/06A61P9/00A61P9/10A61K31/45
Inventor MULLER, GEORGECHEN, ROGERMAN, HON-WAHRUCHELMAN, ALEXANDER
Owner CELGENE CORP
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