Medicinal composition for treatment of chronic hepatitis c

a technology for chronic hepatitis c and composition, which is applied in the direction of drug compositions, antibody medical ingredients, peptide/protein ingredients, etc., can solve the problems of not being able to clarify whether hcv invades a cell or only adheres to its surface, and the infection of chronic hcv becomes a serious problem, so as to prevent side effects of hepatic cirrhosis and enhance immune function
US20070110714A1Inactive Publication Date: 2007-05-17INTPROP CONSULTING +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
INTPROP CONSULTING
Publication Date
2007-05-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a pharmaceutical composition for treating chronic hepatitis C characterized by comprising at least one active ingredient selected from the group consisting of IL-15, myeloid dendritic cell maturation stimulators (for example, CpG oligo deoxynucleotide, GM-CSF, IL-4, LPS, CD40L, polyI:C, TNF-a and IFN-?) and lectin-binding substances (for example, mannose carbohydrate, fucose carbohydrate and anti-lectin antibody); and a method of treating chronic hepatitis C by using such active ingredient(s). In the above pharmaceutical composition and therapeutic method, it is possible to use INF-a together with these active ingredients.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a method and a pharmaceutical composition for treating chronic hepatitis C. BACKGROUND ART

[0002] A hepatitis C virus (HCV) is a single stranded plus sense RNA virus belonging to the Flavivirus family, and causes persistent infection in 70% or more of infected patients. A most important feature of HCV persistent infection is a possibility of progress of hepatic diseases from mild hepatitis to hepatic cirrhosis and hepatic cell carcinoma. The number of patients suffering from HCV positive hepatic cell carcinoma is increasing on a global basis, and chronic HCV infection is becoming a serious problem.

[0003] For preventing progress of hepatic diseases and subsequent onset of hepatic cell carcinoma, it is necessary to eradicate HCV from a HCV-infected patient. For this purpose, a therapy combining IFN-a and ribavirin is currently used as a standard therapeutic method for chronic HCV infection (Japanese Patent Application Laid-Open (...

Claims

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