Oral Compositions Comprising Propolis

Abstract

Oral compositions are provided that comprise a propolis extract; an oral care active compound chosen from: a cationic antibacterial agent, an anti-attachment agent, a biofilm disruption agent, and an anti-inflammatory agent; and a source of fluoride ions. Further, in certain embodiments, the oral composition comprises an anionic polymeric linear polycarboxylate. The oral composition can be in a form of a mouth rinse, a dentifrice, a confectionary, a medicament, or a film. Methods of making and using the oral compositions are also provided.

Description

CROSS REFERENCE TO RELATED APPLICATION [0001] This application claims benefit of U. S. Provisional Patent Application No. 60 / 752,617 filed Dec. 21, 2005, which is incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION [0002] Human periodontal diseases are inflammatory disorders that are the result of complex interactions between period on to pathogens and the host's immune system response. It is believed that there are two interrelated aspects to the progression of periodontal disease; the first is the activation of the immune system of the host and the second is the production of oxygen radicals and their related metabolites. Increased production of oxygen radicals may contribute to oxidative stress, which is believed to be involved in periodontal disease. [0003] Gingivitis is the inflammation or infection of the gums and the alveolar bones that support the teeth. Gingivitis is generally believed to be caused by bacteria in the mouth (particularly the bacteria...

AI Technical Summary

Benefits of technology

[0016] In certain embodiments, the present invention is directed to methods of preventing bacterial from forming a biofilm, suppressing an immune system recognition of an antigen on an oral surface of a mammal, reducing an immune system response, and suppressing production of one or more mediators of inflammation on an oral surface, comprising administering and applying the compositions herein to the oral surface. In certain embodiments, the present invention is directed to methods of maintaining or increasing systemic health of a mammal comprising applying a composition according to claim 1 to the oral surfaces at least once a day a period of time.

Problems solved by technology

Periodontitis is a progressively worsened state of disease as compared to gingivitis, where inflamed gums begin to recede from the teeth, thus forming pockets there between, which can ultimately result in destruction of the bone and periodontal ligament.

Chronic infection and inflammation potentially results in the subsequent loss of teeth.

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