Integrin-linked kinase and its uses

a technology of integrin-linked kinase and kinase, which is applied in the field of integrin-linked kinase, can solve the problems that to date no cellular protein kinase has been identified that has been demonstrated to bind
US20070203326A1Inactive Publication Date: 2007-08-30SUNNYBROOK HEALTH SCI CENT
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
SUNNYBROOK HEALTH SCI CENT
Publication Date
2007-08-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a a continuation of U.S. patent application Ser. No. 09 / 967,854, filed Sep. 28, 2001, which is a Divisional of U.S. patent application Ser. No. 09 / 390,425, filed Sep. 3, 1999, which is a Continuation of U.S. patent application Ser. No. 09 / 035,706, filed Mar. 5, 1998, now issued as U.S. Pat. No. 6,001,622 on Dec. 14, 1999, which is a continuation-in-part of U.S. patent application Ser. No. 08 / 955,841, filed Oct. 21, 1997, now issued as U.S. Pat. No. 6,013,782 on Jan. 11, 2000, which is a continuation-in-part of U.S. patent application Ser. No. 08 / 752,345, filed Nov. 19, 1996, now abandoned which claims priority to provisional patent application No. 60 / 009,074, filed Dec. 21, 1995.INTRODUCTION

[0002] 1. Background

[0003] Proteins of the extracellular matrix (ECM) act to influence fundamental cell and tissue behaviors. ECM regulates cell structure, growth, survival, differentiation, motility and, at the organismal level...

Claims

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