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Allantoin-containing skin cream

a skin cream and allantoin technology, applied in the field of allantoin-containing skin cream, can solve the problems of high degree of stability, difficult to treat blisters by conventional means, and significant degradation of allantoin

Inactive Publication Date: 2008-10-30
ALWYN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]The pH of the composition is in a range of from about 3.0 to about 6.0. This pH range stabilizes the allantoin and makes storage of the composition for extended periods practical. Preferably, the pH of the composition is in a range of from about 5.0 to about 6.0.

Problems solved by technology

However, in such a system with a pH range of 6.8 to 7.5, allantoin degrades significantly with time and in accelerated stability tests at 40° C. Because cosmetics and other preparations designed for application to the skin are typically stored by users at room temperature, and room temperatures can fluctuate with climatic conditions, such a degree of stability is undesirable.
These blisters are difficult to treat by conventional means.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Skin Protectant Over-the-Counter Cream with pH of 7.4 (Prior Art Example)

[0364]A skin protectant over-the-counter (OTC) cream was prepared in accordance with the formulation of Table 1.

TABLE 1COMPOSITION OF ALLANTOIN-CONTAINING SKINCREAM WITH pH OF 7.4INGREDIENTRANGEPREFERREDOPTIMUMPart AWater50.0-90.055.0-75.066.20Sodium Lauryl Sulfate0.50-2.501.00-2.501.90(30%)Propylene Glycol2.0-9.03.0-6.05.30Tetrasodium EDTA0.05-0.500.10-0.300.15Part BLanolin Oil 5.0-15.0 8.0-12.010.60Cetyl Alcohol 3.0-10.03.5-7.56.80Stearyl Alcohol1.0-5.01.0-3.02.00Beeswax0.50-2.501.0-2.51.90Cod Liver Oil1.0-7.01.0-4.02.00BHT0.10-1.000.20-0.800.50Part CSt. John's Wort Extract0.05-0.500.05-0.150.10Witch Hazel Extract0.05-0.500.05-0.150.10Chamomile Extract0.05-0.500.05-0.150.10Arnica Extract0.05-0.500.05-0.150.10Methylparaben0.10-0.500.15-0.400.30Propylparaben0.10-0.500.10-0.300.25Allantoin0.50-2.000.50-2.001.50Fragrance0.05-0.500.10-0.300.20

[0365]The Part A ingredients were combined and heated to ...

example 2

Preparation of a Cream Containing Allantoin with Lower pH

[0367]An OTC skin cream containing allantoin was prepared using the ingredients in Table 3 to provide a cream with a lower pH.

TABLE 3COMPOSITION OF ALLANTOIN-CONTAININGSKIN CREAM WITH pH OF 5.3INGREDIENTRANGEPREFERREDOPTIMUMPart AWater50.0-90.055.0-75.068.68Sodium Lauryl Sulfate0.50-2.501.00-2.501.90(30%)Propylene Glycol2.0-9.03.0-6.05.30Tetrasodium EDTA0.05-0.500.10-0.300.15Citric Acid0.05-0.500.08-0.350.12Part BLanolin Oil 5.0-15.0 8.0-12.010.60Cetyl Alcohol 3.0-10.03.5-7.54.20Stearyl Alcohol1.0-5.01.0-3.02.00Beeswax0.50-2.501.0-2.51.90Cod Liver Oil1.0-7.01.0-4.02.00BHT0.10-1.000.20-0.800.50Part CSt. John's Wort Extract0.05-0.500.05-0.150.10Witch Hazel Extract0.05-0.500.05-0.150.10Chamomile Extract0.05-0.500.05-0.150.10Arnica Extract0.05-0.500.05-0.150.10Methylparaben0.10-0.500.15-0.400.30Propylparaben0.10-0.500.10-0.300.25Allantoin0.50-10.00.50-2.001.50Fragrance0.05-0.500.10-0.300.20

[0368]The Part A ingredients were combine...

example 3

Preparation of Allantoin-Containing Skin Cream with Ionic Emulsifiers

[0372]An allantoin-containing skin cream with ionic emulsifiers is prepared according to Table 5. The preparation follows the method used in Example 2, with the ingredients in each of Part A, Part B, and Part C being combined separately and then Part B being added to Part A, with Part C then being added to the combination of Part A and Part B. The pH is adjusted to a value in a range of from about 5.0 to about 5.8 by neutralizing the stearic acid with enough triethanolamine to reach this pH. Other bases can be used instead of triethanolamine.

TABLE 5ALLANTOIN-CONTAINING SKIN CREAMWITH IONIC EMULSIFIERSINGREDIENTRANGEPREFERREDOPTIMUMPart AWater50.0-90.060.0-85.071.70Propylene Glycol2.0-9.04.0-7.05.70Triethanolamine (99%)0.20-4.0 0.50-3.0 1.25Part BLanolin Oil 5.0-15.0 8.0-12.010.60Cetyl Alcohol1.0-7.02.0-6.03.50Stearic Acid0.50-5.0 1.0-4.02.50Cod Liver Oil1.0-7.01.5-5.02.00Butylated Hydroxytoluene0.10-1.0 0.20-0.800....

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Abstract

An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The composition is in the form of an oil-in-water emulsion. The pH of the composition is in a range of from about 3.0 to about 6.0; preferably, the pH of the composition is from about 5.0 to about 6.0. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant.

Description

CROSS REFERENCES[0001]This application is a continuation-in-part application of application Ser. No. 09 / 758,781, entitled “Allantoin-Containing Skin Cream,” filed Jan. 11, 2001 by Elliott Farber, which in turn was a continuation-in-part application of Ser. No. 09 / 570,266, entitled “Allantoin-Containing Skin Cream,” filed May 12, 2000 by Elliott Farber, which in turn is a continuation-in-part application of application Ser. No. 09 / 360,095, entitled “Oil-in-Water Emulsion With Improved Stability,” filed Jul. 23, 1999 by Elliott Farber, now U.S. Pat. No. 6,281,236, issued Aug. 28, 2001. All three of these prior applications are hereby incorporated in their entirety by this reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]This invention is directed to a skin cream containing allantoin in an oil-in-water emulsion with improved stability.[0004]2. General Background and State of the Art[0005]Allantoin is a commonly used ingredient in cosmetic applications, particul...

Claims

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Application Information

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IPC IPC(8): A61K31/4166A61P17/00A61K9/107A61K8/00A61K8/06A61K8/19A61K8/30A61K8/33A61K8/34A61K8/36A61K8/365A61K8/368A61K8/37A61K8/39A61K8/40A61K8/41A61K8/44A61K8/46A61K8/49A61K8/72A61K8/73A61K8/81A61K8/86A61K8/92A61K8/96A61K8/97A61K8/98A61K9/113A61K31/415A61K31/4164A61K31/4168A61K31/715A61K36/18A61K36/38A61K39/395A61K47/04A61K47/10A61K47/12A61K47/16A61K47/20A61K47/34A61K47/44A61K47/46A61M35/00A61P17/16A61Q17/00A61Q19/00
CPCA61K8/06A61K31/4166A61K8/37A61K8/463A61K8/4946A61K8/73A61K8/8147A61K8/86A61K8/927A61K8/97A61K9/0014A61K47/20A61K47/44A61K2800/5424A61Q17/00A61Q19/00A61Q17/04A61K8/494A61K8/062A61K8/9789A61P17/00A61P17/16A61K8/345A61K8/44A61K8/925A61K9/107A61K47/10
Inventor FARBER, ELLIOTT
Owner ALWYN
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