Cartilage material

a cartilage and material technology, applied in the field of cartilage materials, can solve the problems of enlargement and progression of lesion, limited repair potential of cartilage, and general inability of cartilage to repair itself, and achieve the effect of effective cartilage fluff and cartilage compositions

Inactive Publication Date: 2008-11-13
VIVEX BIOLOGICS GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]The present invention provides one or more significant features. For example, the present invention provides a cartilage fluff or a cartilage composition with demonstrable chondrogenic activity. The cartilage fluff or cartilage composition according to the invention induces new cartilage formation in articular cartilage defects. The cartilage fluff advantageously packs the articular defect without the use of a matrix or vehicle, e.g., glycerol, collagen gel, etc., in combination with the fluff. The cartilage fluff and cartilage composition of the invention show complete or substantially complete regeneration of articular cartilage defects. When placed in a cartilage defect, the inventive cartilage fluff and cartilage composition produce new ca

Problems solved by technology

Cartilage, particularly articular cartilage, of higher animals, including man, has a limited potential for repair.
Following injuries to articular cartilage, the cartilage generally does not repair itself because of its limited capacity for regeneration.
In injuries involving subchondral bone, there is no regen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example

[0032]This example demonstrates the chondrogenic activity of the cartilage fluff in fully immunocompetent non-human primates. Full thickness cartilage defects measuring 10 mm•×•10•mm is created in the medial condyles of the animals. The defects are densely packed with the cartilage fluff according to the present invention and are compacted with a tamp. The animals are examined two, six, and sixteen weeks post transplantation and the joints are re-explored. Photographs taken at two, six, and sixteen weeks, respectively. Specimens are also taken and fixed in 10% formalin-Earle's balanced salt solutions. Paraffin sections are cut and stained with homotoxylin and eosin, PAS, Romanowsli-Giemsa and Safranin-O stains.

[0033]At two weeks post transplantation, granulation tissue is present in the center of the defect and new cartilage is present at the edge of the defect. At six weeks post transplantation, new cartilage is formed from the edges of the defect and granulation tissue is no longe...

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Abstract

Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.

Description

BACKGROUND OF THE INVENTION[0001]Cartilage, particularly articular cartilage, of higher animals, including man, has a limited potential for repair. Following injuries to articular cartilage, the cartilage generally does not repair itself because of its limited capacity for regeneration. The ability to repair is dependent on the extent and the depth of injury and the surviving chondrocytes and normal articular cartilage matrix. In injuries involving subchondral bone, there is no regeneration of the cartilage, but there is typically enlargement and progression of the lesion with associated pain. The ultimate goal of treatment of these lesions is restoration of the cartilage, but in most cases this is not achieved.[0002]Adult articular cartilage is not vascularized and, as stated above, lacks the capacity to regenerate itself after sustaining damage (Vangness, C. T., Jr. et al., Am. J. Orth. 33, No. 25S: 29, 2004). When cartilage is cut, without involvement of subchondral bone, the def...

Claims

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Application Information

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IPC IPC(8): A61K35/32A61F2/02
CPCA61F2/30756A61F2/3094A61F2/30965A61F2002/30764A61F2002/4495A61F2310/00365A61L27/3695A61L27/3612A61L27/3654A61L27/3683A61L27/56A61L2430/06A61L2430/40A61K35/32A61P19/00
Inventor MALININ, THEODORE I.
Owner VIVEX BIOLOGICS GRP INC
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