Method and device for activating stem cells

a stem cell and activation method technology, applied in the field of stem cell activation devices and methods, can solve problems such as unintended side effects, and achieve the effects of enhancing an osteoblast phenotyp
US20100119492A1Inactive Publication Date: 2010-05-13DEPUY SYNTHES PROD INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
DEPUY SYNTHES PROD INC
Publication Date
2010-05-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into osteoblasts capable of forming bone. Devices and methods described include exposing a stem cell source, such as bone marrow aspirate, adipose tissue and / or purified allogenic stem cells, to an active agent, in a manner effective to form activated stem cells.
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Description

RELATED APPLICATIONS

[0001] This patent application claims the benefit of the filing date of U.S. Provisional Patent Application Ser. No. 61 / 110,096, filed Oct. 31, 2008, and entitled, “DEVICE FOR ACTIVATING BONE MARROW ASPIRATE USING EX VIVO STIMULATION BY GROWTH FACTORS FOR IMPROVED BONE FORMATION”, and of U.S. Provisional Patent Application Ser. No. 61 / 152,335, filed Feb. 13, 2009, and entitled, “METHOD AND DEVICE FOR FORMING A BONE MARROW ASPIRATE PRODUCT”, the contents of which are incorporated herein by reference in their entirety.FIELD

[0002] Inventive subject matter described herein relates to devices and methods for activating stem cells, including activating stem cells in bone marrow aspirate using ex vivo stimulation. The inventive subject matter also relates to implants containing such activated stem cells.BACKGROUND OF THE INVENTION

[0003] In order to provide for maximum bone formation, it is desirable to transplant cells that already exhibit an osteoblastic phenotype, becaus...

Claims

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