Light Transmitted Assay Beads

a light-transmitted assay and beads technology, applied in the field of assay beads, can solve the problems of insufficient sample amounts or non-uniform distribution over the chip surface, inability to detect barcodes, inconvenient operation, etc., and achieve the effect of rapid detection rate and rapid detection of fluorescence beads

US20100210477A1Inactive Publication Date: 2010-08-19APPLIED BIOCODE
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
Publication Date
2010-08-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling a 1D or 2D bar code image. To decode the image, the alternating transmissive and opaque sections of the body are scanned in analogous fashion to bar code scanning. The coded bead may be coated or immobilized with a capture or probe to effect a desired bioassay. The coded bead may include a paramagnetic material. A bioanalysis system conducts high throughput bioanalysis using the coded bead, including a reaction detection zone and a decoding zone.
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Description

[0001] This application is a continuation-in-part application of U.S. patent application Ser. No. 11 / 502,606, filed Aug. 9, 2006, which claims the benefit of the priority of Provisional Patent Application No. 60 / 706,896, which was filed Aug. 9, 2005. This provisional application is fully incorporated by reference, as if fully set forth herein. All other publications and U.S. patent applications disclosed herein below are also incorporated by reference, as if fully set forth herein.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The invention relates generally to assay beads and methods for use thereof to carry out bioassays, and more particularly multiplexed bioassays using micro-volume samples, such as protein and nucleic acid analysis.

[0004] 2. Description of Related Art

[0005] As current research in genomics and proteomics produces more multiplexed data, there is a need for technologies that can rapidly screen a large number of nucleic acids and proteins in a very sma...

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Embodiment Construction

[0036]The present description is of the best presently contemplated mode of carrying out the invention. This description is made for the purpose of illustrating the general principles of the invention and should not be taken in a limiting sense. The scope of the invention is best determined by reference to the appended claims.

[0037]For purposes of illustrating the principles of the present invention and not by limitation, the present invention is described herein below by reference to a micro bead that is in the shape of a pallet, and by reference to bioanalysis. However, it is understood that the present invention is equally applicable to micro beads of other overall geometries, and which are applied for other applications requiring identification based on the identity of the beads, without departing from the scope and spirit of the present invention. To facilitate discussion below, the micro bead of the present invention is referred to as a LITAB, which stands for a light transmit...