Articles and methods of treating vascular conditions

a technology of vascular conditions and articles, applied in the field of articles and methods of treating vascular conditions, can solve the problems of mechanical trauma to insufficient delivery and retention of bioactive agents at the vascular treatment site using this approach, and long dwell time at the vascular treatment si

Inactive Publication Date: 2010-09-16
WL GORE & ASSOC INC
View PDF15 Cites 28 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017]The present invention relates to methods of treating or preventing a vascular condition with a thixotropic, turbid, bioactive agent-containing gel material. The method can also be used to treat or repair traumatized vascular structures. The gel material will readily deliver one or more bioactive agents contained by the gel material to a diseased or disease-prone vascular treatment site in need of treatment or repair. In the method, the gel material is capable of being directly injected into luminal spaces of blood vessels and other fluid-conducting anatomical structures with little or no mechanical or chemi...

Problems solved by technology

However, this approach often requires extensive dwell times at the vascular treatment site to ensure adequate delivery and retention of the bioactive agent at the vascular treatment site to treat the vascular condition.
Even with extensive dwell times, the delivery and retention of the bioactive agent at the vascular treatment site using this approach may be insufficient to treat the vascular condition.
The long term implantation of the vascular prosthesis may also result in mechanical trauma to the vascular treatment site due to a nonlubricious nature of the pharmaceutical-containing coating.
The long term implantation of the vascular prosthesis may also result in an unwanted tissue reaction at the vascular treatment site due to the components of the vascular prosthesis and/or the pharmaceutical-containing coating.
The implantation of the DEBs may also result in mechanical trauma to the vascular treatment site due to the components of the DEBs and/or the pharmaceutical-containing coating.
The methods can be challenging as they involve chemical reactions with the blood vessel lumen.
These chemical re...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Articles and methods of treating vascular conditions
  • Articles and methods of treating vascular conditions
  • Articles and methods of treating vascular conditions

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0070]This Example describes the preparation of a thixotropic, turbid gel material that contains a bioactive agent capable of treating vascular tissue in sufficient amounts to treat a vascular condition.

[0071]A first solution (referred herein as Solution 1A) was prepared by mixing phosphate buffered saline (PBS) (0.15M NaCl, pH 7.4, Invitrogen Corporation Carlsbad, Calif.) with 0.40 g / ml hydroxypropyl-β-cyclodextrin (HPβCD) (Sigma-Aldrich, St. Louis, Mo.) and 0.20 g / ml alpha-cyclodextrin (αCD) (Sigma-Aldrich) through stirring and heating (60° C.), followed by adding dexamethasone (Pharmacia & Upjohn Company, Kalamazoo, Mich.) at 20 mg / ml with stirring and heating (60° C.). Solution 1A did not form a gel material and was not turbid.

[0072]A second solution (referred herein as Solution 1B) was prepared by dissolving polyethylene glycol (PEG, Dow Chemical, Midland, Mich.) of average Mn=8 kDa (0.26 g / ml) with PBS. Solution 1B did not form a gel material and was not turbid.

[0073]Equal vol...

example 2

[0074]This Example describes preparation of a thixotropic, turbid gel material that contains a bioactive agent capable of treating vascular tissue in sufficient amounts to treat a vascular condition.

[0075]A first solution (Solution 2A) was prepared by mixing PBS (0.15M NaCl, pH 7.4, Invitrogen) with 0.40 g / ml hydroxypropyl-β-cyclodextrin (HPβCD) (Sigma-Aldrich, St. Louis, Mo.) and 0.20 g / ml alpha-cyclodextrin (αCD) (Sigma-Aldrich) through stirring and heating (60° C.), followed by adding 17β-estradiol (20 mg / ml) (Sigma-Aldrich) by stirring and heating (60° C.). Solution 2A did not form a gel material and was not turbid.

[0076]A second solution (Solution 2B) was prepared by dissolving PEG (Dow Chemical, Midland, Mich.) of average Mn=8 kDa (0.26 g / ml) in PBS. Solution 2B did not form a gel material and was not turbid.

[0077]Equal volumes of Solution 2A and Solution 2B were combined with mixing to form Gel Material B. Gel Material B was turbid, and was opaque and white in appearance.

example 3

[0078]This Example describes preparation of a thixotropic, turbid gel material that contains a bioactive agent capable of treating vascular tissue in sufficient amounts to treat a vascular condition.

[0079]A first solution (Solution 3A) was prepared by mixing PBS (0.15M NaCl, pH 7.4) with 0.40 g / ml hydroxypropyl-β-cyclodextrin (HPβCD) (Sigma-Aldrich, St. Louis, Mo.) and 0.20 g / ml alpha-cyclodextrin (αCD) (Sigma-Aldrich) through stirring and heating (60° C.), followed by adding dicumarol (0.67 mg / ml) (Sigma-Aldrich) by stirring and heating (60° C.). Solution 3A did not form a gel material and was not turbid.

[0080]A second solution (Solution 3B) was prepared by dissolving of PEG (Dow) of average Mn=8 kDa (0.26 g / ml) in PBS. Solution 3B did not form a gel material and was not turbid.

[0081]Equal volumes of solutions 3A and 3B were combined with mixing to form Gel Material C. Gel Material C was turbid, and was opaque and white in appearance.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Massaaaaaaaaaa
Massaaaaaaaaaa
Massaaaaaaaaaa
Login to view more

Abstract

The present invention relates to articles and methods of treating vascular conditions with a thixotropic, turbid, bioactive agent-containing gel material capable of being essentially removed from an implantation site upon re-establishment of fluid flow at the implantation site.

Description

FIELD OF THE INVENTION [0001]The present invention relates to articles and methods of vascular-based therapies to treat a variety of vascular conditions.BACKGROUND OF THE INVENTION [0002]Vascular conditions arise from a variety of causes, and in some cases, necessitate surgical or endovascular intervention. Trauma to the vascular system may also necessitate surgical intervention to treat the traumatized anatomy. The long-term implantation of vascular prostheses including vascular grafts, stent-grafts, and stents, and the application of treatment modalities, including balloon angioplasty are often undertaken to treat vascular conditions including vascular disease and vascular trauma.[0003]Consequences of surgical intervention have been observed following implantation of vascular prostheses including vascular grafts, stent-grafts, stents, and other prostheses, particularly when an anastomosis is formed. The consequences of surgical intervention include, but are not limited to, inflamm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/10A61M37/00A61K31/56A61M25/10
CPCA61K9/0024A61K45/06A61K47/10A61K47/26A61K47/32A61K47/36A61K47/40A61L27/50A61L27/52A61L27/54A61L29/14A61L29/145A61L29/16A61L2300/416A61L2300/802A61K31/565A61K31/573A61K9/06A61P9/00
Inventor CLEEK, ROBERT L.DRUMHELLER, PAUL D.HOLLAND, THERESA A.
Owner WL GORE & ASSOC INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap