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Indazolecarboxamide derivatives for the treatment and prevention of malaria

a technology of indazolecarboxamide and derivatives, applied in the direction of biocide, antiparasitic agents, drug compositions, etc., can solve the problems of major public health problems and achieve the effect of treating and preventing malaria

Inactive Publication Date: 2011-01-27
SANOFI AVENTIS SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This disease represents a major public health problem, with from 300 to 500 million individuals infected and 2.7 million deaths each year, largely children.

Method used

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  • Indazolecarboxamide derivatives for the treatment and prevention of malaria
  • Indazolecarboxamide derivatives for the treatment and prevention of malaria
  • Indazolecarboxamide derivatives for the treatment and prevention of malaria

Examples

Experimental program
Comparison scheme
Effect test

example 1

Compound No. 1

N-(Pyridin-4-yl)-5-pyridin-3-yl-1H-indazole-3-carboxamide hydrochloride

Intermediate 1.1

5-Iodo-1H-indazole-3-carboxylic acid

5-Iodoisatin (5 g, 18.3 mmol) is heated in the presence of sodium hydroxide (0.77 g, 19.2 mmol in 12 ml of H2O) until it is dissolved, and the reaction mixture is then cooled to 0° C. A solution of sodium nitrite precooled to 0° C. (1.26 g, 18.3 mmol in 5.5 ml of H2O) is added. The paste obtained is added portionwise, with vigorous stirring, to a solution of sulphuric acid (3.40 g, 34.8 mmol in 37 ml of H2O) precooled to 0° C. such that the temperature does not exceed 4° C. The stirring is maintained for 15 min and then a tin chloride solution (SnCl2.2H2O, 9.91 g, 43.9 mmol in 15 ml of concentrated HCl) is added slowly such that the temperature does not exceed 4° C. The mixture is left to react for several hours. The reaction mixture is filtered. The solid is washed with boiling water and then taken up with ethanol under hot conditions. The insolub...

example 2

Compound No. 2

N-(Pyridin-4-yl)-5-(4-methyl-[3,4′]-bipyridinyl-5-yl)-1H-indazole-3-carboxamide hydrochloride

Intermediate 2.1

3,5-Dibromo-4-methylpyridine

A solution of n-butyllithium in hexane (1.6 N, 16 ml) is added dropwise, under argon, to a solution of diisopropylamine (3.6 ml, 1.02 equiv.) in anhydrous THF (145 ml) maintained at −10° C. The reaction mixture is cooled to −78° C. and then a solution of 3,5-dibromopyridine (5.92 g, 25 mmol) in THF (200 ml), cooled to −78° C., is added dropwise. The reaction mixture is stirred for 30 min and then methyl iodide (2.17 ml, 1.4 equiv.) is added dropwise. The stirring is maintained for 2 h at −78° C. A saturated aqueous NH4Cl solution (120 ml) is added. After evaporation of the solvents, the reaction mixture is extracted with EtOAc. The organic phase is washed with brine, dried over MgSO4 and evaporated. The yellow solid obtained is taken up with EtOAc. The suspension is filtered. The filtrate is evaporated and the residue is chromatograph...

example 3

Compound No. 3

N-(Pyridin-4-yl)-5-isoquinolin-4-yl-1H-indazole-3-carboxamide

Intermediate 3.1

5-Iodo-1H-indazole-3-carbaldehyde

1 g of sodium nitrite (27.6 g, 400 mmol) is added portionwise, under argon, to a suspension of 5-iodoindole (9.722 g, 40 mmol) in water, followed dropwise by a 6N HCl solution (59 ml). The temperature of the reaction mixture is maintained below 15° C. and the reaction mixture is then left at ambient temperature overnight, with vigorous stirring. The nitrous vapours are expelled under a stream of argon, and the reaction mixture is then filtered. Washing the solid with H2O followed by purification on silica gel (600 g), elution being carried out according to an elution gradient from CH2Cl2 to a CH2Cl2 / EtOAc (9 / 1) mixture, makes it possible to isolate 1.37 g of product in the form of a brown solid.

LC / MS / UV: MH+273 (88.6%)

Intermediate 3.2

5-Iodo-1-(2-trimethylsilylethoxymethyl)-1H-indazole-3-carbaldehyde

Intermediate 3.1 (2.58 g, 9.5 mmol) followed, dropwise, by a so...

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PUM

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Abstract

The invention relates to methods of treating or preventing malaria which comprises administering to a patient in need thereof, an effective amount of a 1H-indazole-3-carboxamide derivative of general formula (I), in the form of a base or of an addition salt with an acid, or in the form of a hydrate or of a solvate of said base or acid addition salt.

Description

SUMMARY OF THE INVENTIONThe invention relates to the use of 1H-indazole-3-carboxamide derivatives, and of their pharmaceutically acceptable salts, for preparing a medicinal product intended for the treatment and prevention of malaria.BACKGROUND OF THE INVENTIONMalaria is a parasitic disease transmitted by mosquitoes of the anopheles type. This disease represents a major public health problem, with from 300 to 500 million individuals infected and 2.7 million deaths each year, largely children. Although it has been eradicated in many regions of the world, malaria continues to progress endemically in Africa, in South-East Asia and in South America, in particular due to resistance of the parasite to some of the molecules used as antimalarial medicinal products, in particular to chloroquine, which has for a long time been the most commonly used molecule.Several species of Plasmodium are responsible for the transmission of malaria to humans, among which Plasmodium falciparum causes the le...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/635A61K31/444A61K31/4725A61K31/4439A61P33/06A61P33/02A61K31/437A61K31/506
CPCA61K31/437A61K31/506A61K31/4725A61K31/444Y02A50/30A61P33/06A61K31/4439A61K31/4706A61K31/416A61K31/4184A61K31/55A61K31/404
Inventor D'ORCHYMONT, HUGUESFRAISSE, LAURENTZIMMERMANN, ANDRE
Owner SANOFI AVENTIS SA
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