Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity

a technology of electrophysiological activity and electrophysiological activity, applied in the field of systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, can solve the problems of increased mortality, potential significant side effects, and inadequate current approaches to cure this arrhythmia, and achieve enhanced therapeutic effect of the therapeutic agent and enhance the therapeutic effect of the therapeutic material

Inactive Publication Date: 2011-10-06
NORTHWESTERN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]In some embodiments, the present invention provides a system comprising 1) a material delivery device, wherein said device comprises an elongate structure configured to access a treatment site within a subject and deliver physical material (e.g., therapeutic agent (e.g., nucleic acid)) to that site; and 2) an energy deliver/monitoring device comprising (a) an elongate member configured for providing access to a treatment site within a subject, (b) an energy-delivery element configured to deliver energy to the treatment site within a subject, and (c) an electrophysiology monitoring element configured to monitor electrical signals (e.g. at or around the treatment site within said subject, such as the heart (e.g., epicardium, endocardium, etc.) or other organs, organ systems, and body systems. In some embodiments, a material delivery device comprises an inner l...

Problems solved by technology

However, targeting a gene ‘cargo’ to an organ of interest presents a variety of challenges.
In addition, systemic delivery carries the risk of unwarranted gene expression in organs that are remote from the region of interest, with the potential for significant side effects.
It is a cause of significant morbidity (such ...

Method used

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  • Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity
  • Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity
  • Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity

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example 1

Denervation of the PLA with Minigene Expressing Gαi Inhibitory Peptide

[0063]Experiments were conducted during development of the present invention with minigene expressing Gαi peptide in a model of AF, which demonstrate that epicardial injection (using an open-chest approach) of minigenes expressing Gαi peptides into the PLA followed by electroporation results in: a) successfully transcription of the minigene with production of Gαi peptide and 2) inhibit of vagal responsiveness in the entire left atrium.

[0064]High-density epicardial mapping was performed in canine subjects using 2×2 electrodes in the PVs, 7×3 electrodes in the PLA, and 7×3 electrodes in the left atrial appendage (LAA). Effective refractory periods (ERPs) were obtained at baseline and in response vagal stimulation (VS)(20 Hz). After baseline mapping, 1 mg (in a volume of up to 2 ml) of either FLAG-tagged Gαi1 / 2 expressing minigene, or FLAG-tagged GαR (random peptide) expressing minigene was injected into the PLA. The...

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PUM

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Abstract

The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]The present application is a Continuation-In-Part of U.S. patent application Ser. No. 12 / 959,864, filed Dec. 3, 2010, which claims priority to U.S. Provisional Application 61 / 266,280, filed Dec. 3, 2009, each of which is herein incorporated by reference in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]This invention was made with government support under Grant No. K08 HL074192 awarded by the National Institutes of Health, the National Heart, Lung, and Blood Institute. The government has certain rights in the invention.FIELD OF THE INVENTION[0003]The invention relates generally to systems and devices for material delivery, energy delivery, and / or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and / or sonoporation to i...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61N1/0412A61N1/327A61N1/20
Inventor ARORA, RISHIKADISH, ALANNG, JASON
Owner NORTHWESTERN UNIV
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