Methods of Preparing Non-Alcohol Bioactive Esential Oil Mouth Rinses

a technology of non-alcohol or reduced alcohol, applied in the field of liquids, can solve the problems of unpleasant mouthwashing sensation, gum burning, and high alcohol consumption of mouthwash users, and achieve the effect of high level of antimicrobial activity

Inactive Publication Date: 2012-01-05
MCNEIL PPC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0029]In further embodiments, a method for preparing a reduced alcohol or non-alcohol, antimicrobial mouth rinse composition is disclosed that exhibits a high level of antimicrobial activity as measured by an M-factor greater than 0.5 (or about 0.5), optionally 1.0 (or about 1.0) optionally, 2.0 (or about 2.0), or optionally 3.0 (or ...

Problems solved by technology

However, the use of high levels of alcohol may sometimes be found unacceptable by some mouthwash users.
Senior citizens have also complained about problems related to gargling with such mouth rinses, and chronic exposure has been found to result in a feeling of gum “burn” resulting from the high concentrations of alcohol.
It has also been reported that alcoholic mouth rinses can result in an unpleasant “dry mouth” sensation.
On the other hand, reducing the levels of alcohol in these mouth rinse compositions can have significant disadvantages.
Such disadvantages include a reduction in the solubility of the mouth rinse actives and/or the other mouth rinse ingredients.
For example, it has been found that lowering alcohol concentr...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Effect of Various Methods of Forming Formulations, and Increasing Surfactant Levels

[0114]Nine propylene-glycol based mouth rinse formulations were prepared by a variety of methods using various surfactants that are approved for use in oral care products. The formulations were tested for turbidity and antimicrobial activity. Turbidity was tested using a Laboratory Turbidimeter Model 2100N from Hach Company (Loveland, Colo.). The formulations were also tested using an in-vitro single species S. mutans biofilm model. A 22-hour S. mutans biofilm was grown (N=96) and exposed to the formulations as well as positive and negative controls for 30 seconds. Sterile water was used as the negative control. After treatment the biofilm was neutralized and rinsed. The biofilm was harvested via sonication using a Misonix XL-2000 Ultrasonic processor (Qsonica, LLC, Newtown, Conn.). Using a Celsis Rapid Detection RapiScreen kit (Celsis International PLC, Chicago). The bacteria was lysed with Celsis Lu...

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Abstract

The invention relates generally to liquids such as mouth rinses for the prevention and elimination of bad breath as well as for the reduction of oral microorganisms responsible for the development of dental plaque and tooth decay. In particular, the present invention relates to a method of preparing non-alcohol or reduced alcohol mouth rinses effective at preventing the above-mentioned problems.

Description

FIELD OF THE INVENTION[0001]The invention relates generally to liquids such as mouth rinses for the prevention and elimination of bad breath as well as for the reduction of oral microorganisms responsible for the development of dental plaque and tooth decay. In particular, the present invention relates to methods of preparing non-alcohol or reduced alcohol mouth rinses effective at preventing the above-mentioned problems.BACKGROUND OF THE INVENTION[0002]Mouth rinse or mouthwash compositions have been used by people for many years for the prevention of bad breath and for the elimination of bacteria and other oral microorganisms that are responsible not only for bad breath but also tooth decay, plaque and gum diseases such as gingivitis and periodontitis. To this end, antiseptic mouthwashes in the past have been designed to clean the oral cavity, provide fresh breath and kill these pathogenic microbes.[0003]Leading antiseptic mouth rinses have traditionally contained alcohol (i.e., et...

Claims

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Application Information

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IPC IPC(8): A61K8/18A61Q11/00
CPCA61K8/34A61K8/345A61K8/347A61K8/368A61K8/4973A61K8/39A61K8/463A61K8/90A61Q11/00A61K8/37A61P1/02A61K8/498A61K8/86A61K8/922A61K2800/30A61K2800/74A61K2800/92
Inventor MORDAS, CAROLYN J.QUEIROZ, DANIEL R.TSAI, PATRICK B.
Owner MCNEIL PPC INC
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