Construct system and uses therefor

a construct system and construct technology, applied in the field of gene expression, can solve the problems of lower than expected translation efficiency, failure to complete a nascent polypeptide chain, and significant obstacles, and achieve the effect of improving sensitivity and determining the translational efficiency or phenotypic preference of different synonymous codons
US20120040367A1Inactive Publication Date: 2012-02-16CORIDON
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
CORIDON
Publication Date
2012-02-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses construct systems and methods for comparing different iso-accepting codons according to their preference for translating RNA transcripts into proteins in cell or tissues of interest or for producing a selected phenotype in an organism of interest or part thereof. The codon preference comparisons thus obtained are particularly useful for modifying the translational efficiency of protein-encoding polynucleotides in cells or tissues of interest or for modulating the quality of a selected phenotype conferred by a phenotype-associated polypeptide upon an organism of interest or part thereof.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates generally to gene expression. More particularly, the present invention relates to construct systems and methods for comparing different iso-accepting codons according to their preference for translating RNA transcripts into proteins in cell or tissues of interest or for producing a selected phenotype in an organism of interest or part thereof. The codon preference comparisons thus obtained are particularly useful for modifying the translational efficiency of protein-encoding polynucleotides in cells or tissues of interest or for modulating the quality of a selected phenotype conferred by a phenotype-associated polypeptide upon an organism of interest or part thereof.BACKGROUND OF THE INVENTION

[0002] The expression of foreign heterologous genes in transformed cells is now commonplace. A large number of mammalian genes, including, for example, murine and human genes, have been successfully expressed in various host cells, includ...

Claims

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