Oral treatment of inflammatory bowel disease

a technology for inflammatory bowel disease and oral treatment, which is applied in the direction of biocide, drug composition, peptide/protein ingredients, etc., can solve the problems of inflamed intestine blood loss, abdominal pain, diarrhea, rectal bleeding, etc., and achieves the effects of reducing the risk of inflammatory bowel diseas

Inactive Publication Date: 2013-07-04
NOVOZYMES AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In patients with IBD, ulcers and inflammation of the inner lining of the intestines lead to symptoms of abdominal pain, diarrhea, and rectal bleeding.
In those with more extensive disease, blood loss from the inflamed intestines can lead to anemia, and may require treatment with iron supplements or even blood transfusions.
Patients with toxic megacolon are extremely ill with fever, abdominal pain and distention, dehydration, and malnutrition.
Azulfidine can cause upset stomach when t

Method used

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  • Oral treatment of inflammatory bowel disease
  • Oral treatment of inflammatory bowel disease
  • Oral treatment of inflammatory bowel disease

Examples

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Effect test

example 1

[0114]10-Day Dextran Sodium Sulphate (DSS)-Induced Colitis Model in the Mouse

[0115]The aim of the following study was to determine the anti-inflammatory activity of human beta defensin 2 in an acute (10-days) model of inflammatory bowel disease (colitis) induced by oral dextran sodium sulphate (DSS) administration in the mouse.

[0116]The DSS colitis mouse model is a well recognized model for studying inflammatory bowel disease, as described in Kawada et al. “Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease”, World J. Gastroenterol., Vol. 13 (42), pp. 5581-5593 (2007); and Wirtz and Neurath “Mouse models of inflammatory bowel disease”, Advanced Drug Delivery Reviews, Vol. 59 (11), 1073-1083 (2007).

[0117]Materials

[0118]Test Items

[0119]Human beta defensin 2 (hBD2); Methylprednisolone 21-hemisuccinate (“prednisolone”), PBS buffer (GIBCO).

[0120]Experimental Animals

[0121]Male C57BL / 6 mice (Harlan Interfauna Iberica, Barcelona,...

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Abstract

The present invention relates to treatment of an inflammatory bowel disease by simultaneous or successive parental and oral administration of a mammalian beta defensin.

Description

RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application No. 61 / 506,437, filed on Jul. 11, 2011 as well as priority under 35 U.S.C. §119 or 365 to European Application No. 11173351.5, filed Jul. 8, 2011.[0002]The entire teachings of the above applications are incorporated herein by reference.INCORPORATION BY REFERENCE OF MATERIAL IN ASCII TEXT FILE[0003]This application incorporates by reference the Sequence Listing contained in the following ASCII text file being submitted concurrently herewith:[0004]a) File name: Sequence Listing.txt; 3 KB in size.BACKGROUND OF THE INVENTIONHuman Defensins[0005]Among many other elements, key components of innate immunity are the antimicrobial peptides (AMPs) that individually show considerable selectivity, but collectively are able to rapidly kill a broad spectrum of bacteria, viruses and fungi. The biological significance of AMPs is emphasized by their ubiquitous distribution in nature and they are probably pr...

Claims

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Application Information

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IPC IPC(8): A61K38/17
CPCC07K14/4723A61K38/1729A61P1/04A61K9/0053
Inventor KJAER, TANJA MARIA ROSENKILDEANDERSEN, BIRGITTEBRINCH, KAROLINE SIDELMANN
Owner NOVOZYMES AS
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