Unlock instant, AI-driven research and patent intelligence for your innovation.

Process for the preparation of strontium ranelate

a technology of strontium ranelate and process, applied in the field of process for the preparation of strontium ranelate, can solve the problems of difficult preparation of completely anhydrous form and high moisture content, and achieve the effects of avoiding formation of impurities due to degradation, high moisture content, and improving purity

Active Publication Date: 2013-11-21
DIVI S LAB LTD
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention describes a process for making a new drug called strontium ranelate. The process involves using a substance called ranelic acid and a non-polar base called dicyclohexylamine to form a salt. This salt is then dissolved in an organic solvent and reacted with strontium halide to produce strontium ranelate. The new process is unique because it avoids the need for high temperatures, which can cause impurities to form. The resulting strontium ranelate has a low moisture content, which makes it more stable and easier to handle.

Problems solved by technology

It is difficult to prepare completely anhydrous form because the strontium halide or strontium hydroxide used in preparing the salt contains certain amount of moisture.
All prior art processes use aqueous medium at the final stage of salt formation which results in high moisture content.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Process for the preparation of strontium ranelate
  • Process for the preparation of strontium ranelate

Examples

Experimental program
Comparison scheme
Effect test

example — 1

EXAMPLE—1

[0018]Ranelic acid (10.0 g, 0. 029 mol) was dissolved in acetone (100 ml) at 25±5° C. to get a clear solution. To this solution was added dicyclohexylamine (13.2 g, 0.0731 mol) while stirring. After 5 hours stirring, the precipitated salt of dicyclohexylammonium ranelate was collected by filtration. The solid was washed with a small amount of acetone and dried at room temperature (Yield: 18.6 g, 90.4%; purity: 99.5% HPLC).

example — 2

EXAMPLE—2

[0019]Ranelic acid (10.0 g, 0. 029 mol) was dissolved in acetonitrile (100 ml) at 25±5° C. to get a clear solution. To this solution was added dicyclohexylamine (13.2 g, 0.0731 mol) while stirring. After 3 hours stirring, the precipitated salt of dicyclohexylammonium ranelate was collected by filtration. The solid was washed with a small amount of acetonitrile and dried at room temperature (Yield: 19.3 g, 94%; purity: 99.5% HPLC).

example — 3

EXAMPLE—3

[0020]Dicyclohexylammonium ranelate (20 g, 0. 028 mol) was dissolved in methanol (100 ml). Separately strontium chloride (11.3 g, 0.071 mol) was dissolved in methanol (100 ml, 0.14% MC) and was added to the solution of dicyclohexylammonium ranelate at 25±5° C. while stirring. After 5 hours stirring, the precipitated salt of strontium ranelate was collected by filtration. The solid was washed with methanol (10 ml×2) and dried under vacuum at room temperature (Yield: 13.3 g, 88.7%; purity: 99.7% HPLC, MC: 1.7%).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
temperatureaaaaaaaaaa
temperatureaaaaaaaaaa
resorptionaaaaaaaaaa
Login to View More

Abstract

Strontium ranelate is prepared by reacting dicyclohexylammonium ranelate with strontium halide in an anhydrous solvent. Strontium ranelate thus obtained will have less than 3% moisture content.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority from India Application 1969 / CHE / 2012, filed May 17, 2012, entitled A PROCESS FOR THE PREPARATION OF STRONTIUM RAN ELATE of which the following is a specification, which application is assigned to the same assignee as this application and whose disclosure is incorporated by reference herein.FIELD OF INVENTION[0002]The present invention discloses a novel process for the preparation of strontium ranelate having less than 3% moisture content.BACKGROUND OF THE INVENTION[0003]Strontium ranelate is distrontium salt of 5-[bis (carboxymethyl) amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid and is represented by formula[0004]Strontium ranelate is used for treating osteoporosis and other bone diseases. It increases bone formation and also reduces bone resorption resulting in a rebalance of bone turnover in favor of bone formation.DESCRIPTION OF THE INVENTION [0005]The preparation of strontium ranelate is des...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): C07D333/40
CPCC07D333/40C07D333/38
Inventor DIVI, MURALI KRISHNA PRASADRAO, MYSORE ASWATHA NARAYANANOWSHUDDIN, SHAIK
Owner DIVI S LAB LTD