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Kits, compositions and methods for detecting a biological condition

Inactive Publication Date: 2014-06-19
LEUKODX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides better tools for detecting and diagnosing biological conditions in patients. This involves using reporter elements that can quickly indicate the presence or absence of biological substances in a sample from a patient. This technology allows for faster diagnosis and treatment of patients, resulting in better outcomes and potentially saving lives.

Problems solved by technology

There are numerous medical conditions which are hard to diagnose.
However, these tests are performed off-line in diagnostic laboratories.
Often, the laboratory services are only provided during a single 8-hour shift during the day and tend to be labor intensive.

Method used

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  • Kits, compositions and methods for detecting a biological condition
  • Kits, compositions and methods for detecting a biological condition
  • Kits, compositions and methods for detecting a biological condition

Examples

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example

Application No. 1—CD64 Infection & Sepsis

[0253]A cartridge 102 (FIG. 1) is prepared for receiving a blood sample. The cartridge comprises a number of treatment composition chambers 106, 108, 110, adapted to respectively house a corresponding number of treatment compositions 120, 122, 124. These compositions are described in further detail in U.S. Pat. No. 8,116,984 and in Davis, B H et al., (2006)), incorporated herein by reference. In brief, Reagent A comprises a mixture of murine monoclonal antibodies (contains buffered saline), Reagent B—10× Concentrated Trillium Lyse solution (contains ammonium chloride), Reagent C—suspension of 5.2 μm polystyrene beads labeled with Starfire Red and fluorescein isothiocyanate (FITC), (contains <0.1% sodium azide and 0.01% Tween 20).

[0254]In a sample transferring step 202 (FIG. 2), a 10 uL blood sample, is transferred from outside apparatus 100 via receiving element 118 into sample composition chamber 104 and then on to treatment chamber 112 in a...

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Abstract

The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The disclosures of the co-pending US Provisional Patent Application to Kasdan, et al, filed on Nov. 17, 2012, and titled “Kits, Compositions and Methods for Detecting a Biological Condition” and the co-pending US Provisional Patent Application to Kasdan, et al, filed on Nov. 17, 2012, and titled “Kits, Compositions and Methods for Rapid Chemical Detection” are incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]The present invention relates generally to apparatus and methods for detecting a biological condition, and more specifically to methods and apparatus for detecting a biological condition in small fluid samples.BACKGROUND OF THE INVENTION[0003]There are numerous medical conditions which are hard to diagnose. Often diagnosis by a physician is based on the physician's observation of combinations of symptoms in a patient. This sometimes leads to misdiagnosis. Furthermore, the patient's response to a treatment...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N2333/70535G01N2333/70596B01L3/5027B01L2300/0816B01L2300/0867B01L2300/0883B01L3/502715B01L2200/10B01L2400/0481G01N33/56972G01N33/68G01N33/5091B01L3/50273G01N33/54386G01N33/6872B01L2400/0406B01L2300/0654B01L2300/18B01L2300/041B01L2300/123B01L2300/0877B01L2200/025G01N2800/26B01L3/502G01N33/569G01N33/5302G01N33/582
Inventor KASDAN, HARVEY LEEMEISSONNIER, JULIENZUTA, YOAVDAVIS, BRUCEROSEN, MICHAHIMMEL, YAELBRODER, YEHOSHUA
Owner LEUKODX
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