Biophotonic materials and uses thereof

a biophotonic material and material technology, applied in the field of biophotonic materials, can solve the problems of low therapeutic efficacy of existing regimens, poor selectivity, and associated undesired side effects, and achieve the effect of promoting skin rejuvenation and skin rejuvenation

Inactive Publication Date: 2014-09-18
KLOX TECH
View PDF9 Cites 19 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0023]In some embodiments, the method is for promoting skin rejuvenation wherein the method comprises placing a biophotonic material over a target skin tissue, wherein the biophotonic material comprises at least one chromophore and a cohesive matrix; and illuminating said biophotonic material with light having a wavelength that overlaps with an absorption spectrum of the at least one chromophore; wherein said biophotonic material emits fluorescence at a wavelength and intensity that promotes skin rejuvenation.

Problems solved by technology

Such regimens, however, are often associated with undesired side-effects, including systemic or localized toxicity to the patient or damage to non-targeted tissue.
Moreover, such existing regimens often demonstrate low therapeutic efficacy due to, for example, the poor selectivity of the photosensitive agents into the target tissues.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biophotonic materials and uses thereof
  • Biophotonic materials and uses thereof
  • Biophotonic materials and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of an Exemplary Cohesive Biophotonic Material

[0195]

% in Composition(wt / wt)Water60-95Glycerine 5-15Propylene Glycol2-6Sodium hyaluronate2-8Urea peroxide1-5Glucosamine sulfate0.5-4  Carbopol0.1-2  First Chromophore 0.001-0.01 Second chromophore0.001-0.01 

[0196]Phase A was prepared by mixing water, Eosin Y, Rose Bengal and Glucosamine sulphate. Phase B (Water, Glycerin, Propylene glycol, Urea peroxide, Carbopol polymer) was then added to Phase A, and mixed until a light viscous liquid was obtained. Phase C (Sodium hyaluronate) was then added to the mixture, and mixed until a homogenous thick gel was obtained.

[0197]The homogenous gel obtained above was spread onto a flat surface. The layer was covered with an aluminum sheet and was allowed to dry for 24 hours. After 24 hours, the resulting material was a cohesive gel, was elastic and easy to manipulate. It could be applied to the skin and pealed off with little or no residue remaining A 5-20% weight loss of the total weight ...

example 2

Measurement of Tensile Strength

[0198]The tensile strength of a biophotonic material formed according to Example 1 may be measured by the following method. Pieces of the biophotonic material having a size of about 2 cm×2 cm, and 2 mm thickness are prepared. The tensile strength of the biophotonic material pieces is then measured using a 500N capacity tabletop mechanical testing system (#5942R4910, Instron) with a 5N maximum static load cell (#102608, Instron). Pneumatic side action grips are used to secure the samples (#2712-019, Instron). A constant extension rate of 2 mm / min until failure is used and the tensile strength is calculated from the stress vs. strain data plots. Stress-strain testing is detailed by standards-setting organizations, notably the American Society for Testing and Materials (ASTM). A preferred method is ASTM D638.

example 3

Measurement of Tear Strength

[0199]The tear strength of a biophotonic material formed according to Example 1 may be measured by any American Society for Testing and Materials (ASTM) methods known in the art. A preferred method is ASTM D1004.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
wavelengthaaaaaaaaaa
wavelengthaaaaaaaaaa
Login to view more

Abstract

The present disclosure provides biophotonic materials and methods useful in phototherapy. In particular, the biophotonic materials of the present disclosure include a cohesive matrix, and at least one chromophore, wherein the at least one chromophore can absorb and emit light from within the biophotonic material. The biophotonic materials and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

Description

CROSS-RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 61 / 786,197, filed Mar. 14, 2013, and U.S. Provisional Application Ser. No. 61 / 873,747, filed Sep. 4, 2013, the entire contents of each of which are incorporated herein by reference.BACKGROUND OF THE DISCLOSURE[0002]Phototherapy has recently been recognized as having wide range of applications in both the medical and cosmetic fields including use in surgery, therapy and diagnostics. For example, phototherapy has been used to treat cancers and tumors with lessened invasiveness, to disinfect target sites as an antimicrobial treatment, to promote wound healing, and for facial skin rejuvenation.[0003]Photodynamic therapy is a type of phototherapy involving the application of a photosensitive agent to target tissue then exposing the target tissue to a light source after a determined period of time during which the photosensitizer is absorbed by the target tissue. Such regimens, how...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K41/00B65D83/14A61N5/06
CPCA61K41/0057A61N5/062A61N2005/0662B65D83/14A61N5/0616A61K8/498A61Q19/00A61Q19/08A61K8/042A61K8/0212A61K8/0216A61K2800/434A61P1/02A61P17/00A61P17/02A61P17/04A61P17/06A61P17/10A61K8/02A61K9/00A61K41/00A61L15/42A61N5/06A61K47/32A61N2005/0658A61K8/735A61K47/36A61K2800/81A61M11/00
Inventor PIERGALLINI, REMIGIOLOUPIS, NIKOLAOS
Owner KLOX TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap