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Biophotonic materials and uses thereof

a biophotonic material and material technology, applied in the field of biophotonic materials, can solve the problems of low therapeutic efficacy of existing regimens, poor selectivity, and associated undesired side effects, and achieve the effect of promoting skin rejuvenation and skin rejuvenation

Inactive Publication Date: 2014-09-18
KLOX TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a method for treating skin disorders using a biophotonic material that is applied to the skin and then illuminated with light. The light is absorbed by the material, causing it to emit light at a specific wavelength and intensity that helps to heal the skin disorder. The technical effect is a non-invasive, effective treatment for skin disorders that is based on phototherapy.

Problems solved by technology

Such regimens, however, are often associated with undesired side-effects, including systemic or localized toxicity to the patient or damage to non-targeted tissue.
Moreover, such existing regimens often demonstrate low therapeutic efficacy due to, for example, the poor selectivity of the photosensitive agents into the target tissues.

Method used

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  • Biophotonic materials and uses thereof
  • Biophotonic materials and uses thereof
  • Biophotonic materials and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of an Exemplary Cohesive Biophotonic Material

[0195]

% in Composition(wt / wt)Water60-95Glycerine 5-15Propylene Glycol2-6Sodium hyaluronate2-8Urea peroxide1-5Glucosamine sulfate0.5-4  Carbopol0.1-2  First Chromophore 0.001-0.01 Second chromophore0.001-0.01 

[0196]Phase A was prepared by mixing water, Eosin Y, Rose Bengal and Glucosamine sulphate. Phase B (Water, Glycerin, Propylene glycol, Urea peroxide, Carbopol polymer) was then added to Phase A, and mixed until a light viscous liquid was obtained. Phase C (Sodium hyaluronate) was then added to the mixture, and mixed until a homogenous thick gel was obtained.

[0197]The homogenous gel obtained above was spread onto a flat surface. The layer was covered with an aluminum sheet and was allowed to dry for 24 hours. After 24 hours, the resulting material was a cohesive gel, was elastic and easy to manipulate. It could be applied to the skin and pealed off with little or no residue remaining A 5-20% weight loss of the total weight ...

example 2

Measurement of Tensile Strength

[0198]The tensile strength of a biophotonic material formed according to Example 1 may be measured by the following method. Pieces of the biophotonic material having a size of about 2 cm×2 cm, and 2 mm thickness are prepared. The tensile strength of the biophotonic material pieces is then measured using a 500N capacity tabletop mechanical testing system (#5942R4910, Instron) with a 5N maximum static load cell (#102608, Instron). Pneumatic side action grips are used to secure the samples (#2712-019, Instron). A constant extension rate of 2 mm / min until failure is used and the tensile strength is calculated from the stress vs. strain data plots. Stress-strain testing is detailed by standards-setting organizations, notably the American Society for Testing and Materials (ASTM). A preferred method is ASTM D638.

example 3

Measurement of Tear Strength

[0199]The tear strength of a biophotonic material formed according to Example 1 may be measured by any American Society for Testing and Materials (ASTM) methods known in the art. A preferred method is ASTM D1004.

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Abstract

The present disclosure provides biophotonic materials and methods useful in phototherapy. In particular, the biophotonic materials of the present disclosure include a cohesive matrix, and at least one chromophore, wherein the at least one chromophore can absorb and emit light from within the biophotonic material. The biophotonic materials and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

Description

CROSS-RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 61 / 786,197, filed Mar. 14, 2013, and U.S. Provisional Application Ser. No. 61 / 873,747, filed Sep. 4, 2013, the entire contents of each of which are incorporated herein by reference.BACKGROUND OF THE DISCLOSURE[0002]Phototherapy has recently been recognized as having wide range of applications in both the medical and cosmetic fields including use in surgery, therapy and diagnostics. For example, phototherapy has been used to treat cancers and tumors with lessened invasiveness, to disinfect target sites as an antimicrobial treatment, to promote wound healing, and for facial skin rejuvenation.[0003]Photodynamic therapy is a type of phototherapy involving the application of a photosensitive agent to target tissue then exposing the target tissue to a light source after a determined period of time during which the photosensitizer is absorbed by the target tissue. Such regimens, how...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K41/00B65D83/14A61N5/06
CPCA61K41/0057A61N5/062A61N2005/0662B65D83/14A61N5/0616A61K8/498A61Q19/00A61Q19/08A61K8/042A61K8/0212A61K8/0216A61K2800/434A61P1/02A61P17/00A61P17/02A61P17/04A61P17/06A61P17/10A61K8/02A61K9/00A61K41/00A61L15/42A61N5/06A61K47/32A61N2005/0658A61K8/735A61K47/36A61K2800/81A61M11/00
Inventor PIERGALLINI, REMIGIOLOUPIS, NIKOLAOS
Owner KLOX TECH
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