Cancer cell inhibitory drug and cancer stem-cell detection probe

Inactive Publication Date: 2015-07-02
CANON KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0020]Owing to the compound provided by the present invention, growth suppression, cellular division suppression, metastasis suppression, functional inhibition and cytocidal action of cancer cells can be mediated even in sites where cancer cells are overlooked by surgical excision and hardly excised out. More specifically, the present invention provi

Problems solved by technology

However, the radioactive compound may affect normal cells.
Therefore, w

Method used

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  • Cancer cell inhibitory drug and cancer stem-cell detection probe
  • Cancer cell inhibitory drug and cancer stem-cell detection probe
  • Cancer cell inhibitory drug and cancer stem-cell detection probe

Examples

Experimental program
Comparison scheme
Effect test

Example

Example 1

[0159]Production Examples of the compounds of the present invention will be shown.

[0160]Production of Compound (1)

Under a nitrogen atmosphere, to a solution of compound (A1) (0.61 g (2.0 mmol)) in anhydrous acetic acid (10 mL), a compound (B1) (0.20 g (1.0 mmol)) and anhydrous sodium acetate (0.16 g (2.0 mmol)) were added and stirred at 100° C. for one hour. After completion of the reaction, while the reaction solution was cooled, saturated saline (100 mL) was gently added dropwise to cool the reaction solution to room temperature. Furthermore, the reaction solution was extracted twice with dichloromethane (50 mL) and dried over anhydrous sodium acetate. Thereafter, the organic layer was concentrated under reduced pressure. The residue was purified by silica gel chromatography and the purified product was recrystallized from diethyl ether to obtain the compound (1) (0.29 g (yield 59%)). The desired product was confirmed by 1H nuclear magnetic resonance spectroscopic analysi...

Example

Example 2

Measurement of Fluorescent Property of Compound

[0164]A 5 μM DMSO solution of each of the compounds shown in the following Table 1 was prepared. The excitation wavelength and fluorescence wavelength of the compound were measured by a FL4500 spectrofluorometric measuring machine manufactured by Hitachi High-Technologies Corporation.

TABLE 1ExcitationFluorescenceCompoundwavelengthλexwavelength λemCompound 1485575Compound 4563569Compound 5560628Compound 7344381Compound 10586615Compound 11354469Compound 14491510Compound 16474509Compound 17492511Compound 18492510Compound 20516602Compound 21473564Compound 22553570Compound 24496569Compound 26684710Compound 27650675Compound 28589614Compound 30643662Compound 34638661Compound 35571620Compound 37650770Compound 40819825Compound 43797816Compound 45665681Compound 46679715Compound 47615637Compound 49830831Compound 50831833Compound 54774800Compound 55688715Compound 59804520Compound 60670696

Example

Example 3

Confirmation on Cancer Cell Inhibitory (Growth Suppressive) Action Against Pancreatic Cancer Cells

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Abstract

An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient.

Description

TECHNICAL FIELD[0001]The present invention relates to a cancer cell inhibitory drug, particularly to a cancer stem cell inhibitory drug, and a cancer stem-cell detection probe.BACKGROUND ART[0002]At present, as a general cancer therapy, e.g., radiation therapy, chemotherapy, immunotherapy and surgical (excision) therapy are mentioned. The chemotherapy is a method for suppressing cancer by use of an anticancer therapeutic agent made of various types of low-molecular compounds.[0003]The therapy using an anticancer therapeutic agent is directed to reduce the size of a solid tumor. However, the most part of a tumor is occupied by differentiated cancer cells which no longer have a function as a cancer stem cell and it is pointed out in a general anticancer agent treatment that the differentiated cancer cells are only targeted to reduce the size thereof.[0004]Cancer has cells having nature of stem cells, called cancer stem cells.[0005]The cancer stem cells, which were first identified in ...

Claims

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Application Information

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IPC IPC(8): A61K31/4709G01N33/58A61K31/404A61K31/428A61K31/423
CPCA61K31/4709A61K31/428G01N33/582A61K31/404A61K31/423A61K41/0038A61K49/0032C09B23/0008C09B23/0016C09B23/0025C09B23/0033C09B23/0066C09B23/06C09B23/083C09B23/086A61K45/06A61P35/00A61P43/00A61K2300/00A61K31/403
Inventor SHINTOU, TAICHINOMOTO, TSUYOSHIWATANABE, KOHEIMIYAZAKI, TAKESHITANAKA, TOSHIOSHIMADA, YASUHITONISHIMURA, YUHEI
Owner CANON KK
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