Treatment of Migraine Headaches with Presynaptic Neurotoxin
a neurotoxin and migraine technology, applied in the field of migraine headache treatment, to achieve the effect of reducing doses, reducing side effects of botulinum toxin, and reducing side effects
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case 4
[0099]28-year old woman is involved in a motor vehicle accident with blunt head trauma that results in an acute left epidural hematoma. She undergoes urgent craniotomy. The hematoma is evacuated via a left prieto-temporal craniotomy. She gradually recovers but her course is complicated by ongoing headaches overt the left hemicranium. These are throbbing in nature, interfere with her activities, and associated with nausea and vomiting. These headaches are present on a near daily basis. She is successfully treated with onabotulinumtoxinA in accordance with the injection methodology as outlined in case 1 above.
Aspect 2.
Case 1
[0100]43-year old woman, with a long standing history of migraine, suffers with headache on twenty (20) days out of each month and requires triptan medication on twelve (12) days out of each month to try and control her more disabling headaches. She meets criteria for chronic migraine complicated by medication overuse headache. She fails to respond to numerous prev...
case 3
[0113]64-year old bald man has a long history of migraines dating back to his teens. He now presents with headaches mainly involving the vertex of the head. These occur about 8 days a month. They are disabling, worsened by head movement and associated with sensitivity to light and noise. These are diagnosed as episodic migraine. His neurological examination and brain imaging studies are normal for age. The only exception is that he has senile ptosis.
[0114]Treatment options are reviewed with the patient. He wants to try a preventive approach to avoid getting these disabling headaches. He wants to try onabotulinumtoxinA. However, injections of the frontalis are contra-indicated as these will worsen the senile brow ptosis and in addition the headaches are only located over the vertex of the head.
[0115]OnabotulinumtoxinA is successfully used to treat his headaches using the method described in this invention.
[0116]100 units of onabotulinumtoxinA is diluted in 10 cc of normal saline. The...
case 1
ne Associated Vertigo
[0135]A 54 year old man presented with a long history of vertigo. The onset of vertigo began with minor episodes while the patient was in college. It then presented acutely with an incapacitating episode. The following year, the vertigo then recurred periodically. The patient then had an episode that lasted for 1 month with both symptoms of spinning and imbalance. The patient was worked up diagnostically by ear specialists, otologists, neurologists. Allergy testing was negative. Numerous CT and MRI scans and inner ear testing all proved to be normal with no evidence of tumors or vascular lesions. The diagnosis was confirmed by numerous specialists to be migraine associated vertigo or that of possible vascular origin. Treatment included various antihistamines such as diphenhydramine, meclizine hydrochloride, and scopolamine which did not control the symptoms of vertigo.
[0136]During the past 12 months, prior to initial consultation, the vertigo at times became inc...
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Abstract
Description
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