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Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone

Inactive Publication Date: 2016-02-25
JOHNSON MATTHEY PLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes an improved process for making certain compounds, such as oxycodone, that have reduced levels of unwanted byproducts. These improvements can lead to easier handling and processing of the compounds, as well as improved appearance and reduced color. The patent also provides methods for making other compounds, such as oxymorphone, with reduced levels of different byproducts. Overall, this patent aims to provide a more efficient and effective way to produce high-quality opioid compounds.

Problems solved by technology

According to the U.S. Food and Drug Administration (“FDA”), ABUKs have been demonstrated to be reactive with DNA, resulting in genotoxicity.
Potentially genoxic compounds present a safety concern because the compounds pose a cancer risk.

Method used

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  • Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
  • Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
  • Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone

Examples

Experimental program
Comparison scheme
Effect test

example 1

Comparative

[0084]A 500 mL jacketed reaction vessel is charged with 85% formic acid (26.1 g, 480 mmol, 15.0 equivalents) and then thebaine (12.5 g wet, 10 g dry, 32 mmol) is added while stirring and maintaining the temperature at <35° C. The resulting solution is cooled to 25-30° C. and then 30% w / w hydrogen peroxide solution in water (4.0 g, 35.2 mmol, 1.1 equivalents) is added over 30-45 minutes while maintaining the reaction temperature in the 25-30° C. range. The reaction mixture is stirred at 25-30° C. for 9 h, then cooled to 0-10° C. and held for 11 h.

[0085]A 1:1 v / v mixture of 28-30% ammonium hydroxide solution and water (˜64 mL) is next added to adjust the pH to 9.3 (target 8.5-9.5) while maintaining the temperature at <30° C. The resulting mixture is stirred at 0-10° C. for 30 min and a product (a white sticky solid) is filtered, washed with water (30 mL) and then ethanol (20 mL). The wet product is allowed to dry on the filter under applied vacuum for 6 min to afford a crud...

example 2

[0086]A 500 mL jacketed reaction vessel is charged with 85% formic acid (26.1 g, 480 mmol, 15.0 equivalents) and then thebaine (12.5 g wet, 10 g dry, 32 mmol)) is added while stirring. The resulting solution is stirred, the temperature is adjusted to 25-30° C. and sulfuric acid (1.26 g, 0.7 mL, 12.8 mmol, 0.4 equivalents) is added cautiously with the batch temperature increasing from 27° C. to 33° C. A 30% w / w hydrogen peroxide solution in water (4.0 g, 35.2 mmol, 1.1 equivalents) is next added over 1.5 h while maintaining the reaction temperature in the range 25-30° C. The reaction mixture is stirred at 25-30° C. for 10 h, then cooled to 0-10° C. and held for 10 h.

[0087]A 1:1 v / v mixture of 28-30% ammonium hydroxide solution and water (70 mL) is next added to adjust the pH to 9.2 (target 8.5-9.5) while maintaining the temperature at <30° C. The resulting mixture is stirred at 0-10° C. for 1.5 h and a solid product is filtered, washed with water and then methanol. The wet product is...

example 3

[0088]A 1 L reaction vessel is charged with 85% formic acid (26.1 g, 480 mmol, 15.0 equivalents) and then thebaine (12.5 g wet, 10 g dry, 32 mmol)) is added while stirring. The resulting solution is stirred and the temperature is adjusted to 25-30° C. and trifluoroacetic acid (2.9 g, 1.9 mL, 25.7 mmol, 0.8 equivalents) added cautiously. A 30% w / w hydrogen peroxide solution in water (4.0 g, 35.2 mmol, 1.1 equivalents) is next added over 1.25 h. The reaction mixture is stirred at 25-30° C. for 8 h, then cooled to 0-5° C. and held for 8 h.

[0089]A 1:1 v / v mixture of 28-30% ammonium hydroxide solution and water is next added to adjust the pH to within 8.5-9.5 range while maintaining the temperature at <30° C. The resulting mixture is stirred at 0-5° C. for 2 h and a solid product is filtered, washed with water and then methanol. The wet product is allowed to dry on the filter under applied vacuum to afford crude 14-hydroxycodeinone (wet product weight 15.9 g, dry product weight 8.90 g, c...

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PUM

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Abstract

Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.

Description

FIELD OF THE INVENTION[0001]The present disclosure relates generally to improved processes for making opioid products having low impurity levels. More specifically, the disclosure relates to improved processes for making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.BACKGROUND OF THE INVENTION[0002]As with other pharmaceutical products, it is desirable to attain improvements with respect to opioid product safety. In particular, there is a continuing need in the art to provide improved processes for making high quality, synthetic or partially synthetic opioid compounds.[0003]Opioids are among the world's oldest known drugs as the therapeutic use of the opium poppy predates recorded history. The term “opioid” refers to both opiates (i.e., natural alkaloids found in the resin of the opium poppy) and synthetic substances, and is typically defined as any psychoactive chemical that resembles morphine or other opiates in its pharmacological effects....

Claims

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Application Information

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IPC IPC(8): C07D489/08
CPCC07D489/08G06F3/061G06F3/0632G06F11/1076G06F3/0611G06F3/0644G06F3/0689G06F11/10
Inventor MATHARU, SAROOP SINGHHEINRICH, BRIAN W.GRANT, EWARTZHANG, HONGZHI
Owner JOHNSON MATTHEY PLC
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