Succinate dehydrogenase inhibitor containing compositions

a technology of succinate dehydrogenase and composition, which is applied in the field of compositions containing succinate dehydrogenase inhibitors, can solve the problems that many potential uses of these compounds cannot be achieved, and achieve the effect of reducing the amount of the inhibitor and improving the efficacy

Inactive Publication Date: 2016-10-06
ARCH WOOD PROTECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]In one aspect, the present invention provides composition comprising a succinate dehydrogenase inhibitor and an effective amount of a potentiator. It has been discovered that the composition has improved efficacy against microbes, as compared to the inhibitor itself and that the amount of the inhi

Problems solved by technology

However, it is known in the art that the use of succinate dehydrogenase inhibitor at low application rates or doses may result in unsatis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0068]Sample stock solution of Penflufen was prepared in DMSO at 20000 ppm (active ingredient). Serial dilutions of Penflufen and the potentiators were made in DMSO in a 96 well plate and 10 ul of solution from each well was transferred into a new flat bottom 96 well plate to run a microtiter plate minimum inhibitory concentration (MIC) test. The potentiators tested are shown in Table 1.

TABLE 1PotentiatorsPotentiatorChemical name / compositionEthoduomeenTris(2-hydroxyethyl)-N-tallowalkyl-1,3-diaminopropaneBarlene 12N,N-DimethyldodecylamineHPNO2-hydroxypyridine-N-oxideBarlox 12cocoamine oxideIsononoic Acid—Oleylamine(Z)-Octa-9-decenylamineToluene—sulfonamideDHA ZnDehydroascorbic acid zinc salt

[0069]Microorganisms grown on agar slants were harvested using standard microbiological techniques. The numbers of mold spores were determined by counted using a hemocytometer, and then inoculum was prepared in the media shown in Table 2. Then, 190u1 of inoculum was added into each well containing...

example 2

[0072]Total 17 samples, including Penflufen, 8 Penflufen-potentiator blends and 8 potentiators were submitted for evaluation. The concentrations of Penflufen and potentiators in the samples are shown in Table 4.

TABLE 4ActivePotentiatorRatio ofConc.conc.Sample NamePot. / Act.(ppm)(ppm)Penflufen blend with Barlene 121x10,00010,000Penflufen blend with Barlox 12  0.5x10,0005,000Penflufen blend with Ethoduomeen5x10,00050,000Penflufen blend with Sodium benzoate5x10,00050,000Penflufen blend with Oleylamine  0.1x10,0001,000Penflufen blend with HPNO5x10,00050,000Penflufen blend with Isononoic Acid5x10,00050,000Penflufen blend with DHA-Zn1x10,00010,000Barlene 1210,000Barlox 125,000Ethoduomeen50,000Sodium benzoate50,000Oleylamine1,000HPNO50,000Isononoic Acid50,000DHA-Zn10,000Penflufen10,000

[0073]Procedure

[0074]Decay fungi Antrodia sinuosa and Coniophora puteana were obtained from GTS microbiology lab fungal collection and cultured on Potato Dextrose Agar at 28° C.

[0075]The samples were diluted t...

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Abstract

A composition containing succinate dehydrogenase inhibitor and a potentiator has been discovered to enhance the activity of the succinate dehydrogenase such that the amount of the succinate dehydrogenase inhibitor need to effectively treat a microbial substance can be reduced substantially. The compositions may be used as additives for paints and coatings, and protecting crops, seeds, wallboard, metal working fluids, wood from mold, fungi and other microbes.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a composition of containing a succinate dehydrogenase inhibitor, and uses thereofBACKGROUND OF THE INVENTION[0002]The use of succinate dehydrogenase (SDH) inhibitors for controlling phytopathogenic fungi and microorganisms is known from the prior art. For example, U.S. Pat. No. 7,538,073, which is incorporated by reference in its entirety, describes the use of the succinate dehydrogenase (SDH) inhibitor N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (referred to below by the common name penflufen) for controlling unwanted microorganisms and phytopathogenic fungi. However, it is known in the art that the use of succinate dehydrogenase inhibitor at low application rates or doses may result in unsatisfactory results.[0003]Combinations of succinate dehydrogenase inhibitors with other active compounds have been suggested in the art. For example, US Patent Application publication 2008 / 0293566A1 d...

Claims

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Application Information

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IPC IPC(8): A01N43/56A61K8/49B27K3/36C09D5/14C09D4/00A01N55/02A61Q5/00
CPCA01N43/56A01N55/02A61K8/494B27K2240/20C09D5/14C09D4/00B27K3/36A61Q5/006B27K1/00A01N25/30A01N33/04A01N33/12A01N33/24A01N41/06A01N43/08A01N43/40A01N33/00A01N37/02A01N43/16A61K8/361A61K8/41A61K8/466A61K8/4926A61K8/498A61K8/58
Inventor POLSON, GEORGEVALCKE, ALEXHUGHES, ANDREWJOURDEN, JODYPRIOLI, MARIA REGINAZHENG, QI
Owner ARCH WOOD PROTECTION
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