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Cosmetic compositions capable of producing localized surface plasmonic resonance in response to indoor and/or outdoor lighting sources

Inactive Publication Date: 2018-11-01
SABIC GLOBAL TECH BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes a solution for using plasmonic metal nanostructures in topical skin care compositions, such as cosmetic products. These nanostructures can produce therapeutically effective amounts of LSPR (localized surface plasmon resonance) in both natural light and artificial light settings, providing consistent skin benefits regardless of the light source. The nanostructures can also be designed to have specific peaks that match the light source, allowing for a more robust LSPR response in both indoor and outdoor settings. The produced LSPR can reduce free radicals and oxidants in the skin, providing benefits such as reducing skin damage and inflammation. The topical skin care compositions are dermatologically acceptable and can have a selected viscosity to prevent dripping or pooling after application.

Problems solved by technology

Notably, however, the Chung et al. pigments fail to consider the stability of their optical properties when the light source varies.
In particular, the pigments in Chung et al. can be prone to not exhibiting the desired colors when exposed to artificial light versus natural sunlight, thereby presenting a problem with obtaining a desired and consistent color irrespective of the light source.
Similar to Chung et al., Harris et al. also fails to explain whether the plasmonic nanoparticles can produce the thermomodulation effect irrespective of whether the composition having the nanoparticles exposed to natural or artificial light.
Stated plainly, the compositions in Harris et al. fail to address a situation where the end user applying the composition may move from an environment that has natural light to an environment that largely includes artificial light (e.g., an office environment, a home, etc.) and unknowingly reduces the efficacy of the composition.
Similar to Harris et al., El-Sayed et al. also fails to address the situation where the light source may vary, thereby reducing the efficacy of the composition when the light source switches from an artificial light source to natural sunlight, and vice versa.

Method used

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  • Cosmetic compositions capable of producing localized surface plasmonic resonance in response to indoor and/or outdoor lighting sources
  • Cosmetic compositions capable of producing localized surface plasmonic resonance in response to indoor and/or outdoor lighting sources
  • Cosmetic compositions capable of producing localized surface plasmonic resonance in response to indoor and/or outdoor lighting sources

Examples

Experimental program
Comparison scheme
Effect test

example 1

Prophetic Method of Making Plasmonic Noble Metal Nanoparticles

[0058]Seeded growth is the major method for producing gold nanorods. The sub 2 nm seed is synthesized by adding HAuCl4 (0.01 M) into a CTAB (0.1 M) solution. After mixing for 30 minutes, chilled NaBH4 will be added under vigorous stirring. Then the mixture will be heated gently for about 20 minutes at 60° C. to obtain the seed solution. The growth solution will be include 0.1 M CTAB, 0.01 M HAuCl4, 0.01 M AgNO3, and 0.1 M Ascorbic acid. The seed solution will be added to the growth solution to obtain gold nanorods. The Aspect ratio will be tuned by adjusting the conditions of the growth solution; including the CTAB concentration, silver ion concentration, HAuCl4 concentration, growth temperature and duration, and solvent. Potential suppliers of nanoparticles are Nanopartz Inc., Loveland, Colo. (USA), NanoComposix, Inc. San Diego, Calif. (USA) and Sona Nanotech Ltd (Canada).

##ic example 2

Prophetic Example 2

Blends of Plasmonic Noble Metal Nanoparticles

[0059]The following procedure can be followed to identify appropriate plasmonic noble metal nanoparticle blends or combinations (e.g., combinations of gold nanorods having different plasmonic peaks) that can be used in the topical skin compositions of the present invention. First, a selection of specific gold nanorods having different aspect ratios can be identified. As discussed above, the differing aspect ratios can result in different plasmonic peaks, with larger aspect ratios resulting in plasmonic peaks that have a longer wavelength and smaller aspect ratios resulting in plasmonic peaks having a shorter wavelength. Second, evaluation of the gold nanorods can be performed by comparing the areas under the absorbance peaks of the nanorods vis-à-vis a gold spherical nanoparticle. By way of example, FIG. 1 provides an absorbance comparison of gold (Au) nanospheres (NPS) having a diameter of 30 nm with gold (Au) nanorods...

##ic example 3

Prophetic Example 3

Preparation of a Topical Skin Care Composition and Efficacy of the Composition

[0060]The following includes an in vitro bioassay that can be used to measure the anti-oxidant capacity of any one of the plasmonic noble metal nanostructures or combinations of such nanostructures disclosed in the specification. The assay relies on the ability of a sample formulation having the nanostructures of the present invention to inhibit the oxidation of ABTS® (2,2′-azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS®+by metmyoglobin. The capacity of the nanostructures present in the formulation to prevent ABTS oxidation is compared with that of Trolox, a water-soluble tocopherol analogue, and is quantified as molar Trolox equivalents. Anti-Oxidant capacity kit # 709001 from Cayman Chemical (Ann Arbor, Mich. USA) can be used for this in vitro bioassay. The protocol can be followed according to manufacturer recommendations. A light source can be used that would trigger an LSPR re...

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PUM

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Abstract

A topical skin composition and methods for its use are described. The composition can include a plurality of first plasmonic noble metal nanostructures having an aspect ratio of greater than 1 and being configured to absorb electromagnetic radiation from an artificial light source and / or from a solar radiation source to produce a first localized surface plasmon resonance (LSPR), and a plurality of second plasmonic noble metal nanostructures having an aspect ratio of greater than 1 and being configured to absorb electromagnetic radiation from a solar radiation source to produce a second LSPR.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application Ser. No. 62 / 490,902 filed Apr. 27, 2017, which is incorporated by reference in its entirety without disclaimer.BACKGROUND OF THE INVENTIONA. Field of the Invention[0002]The invention generally concerns topical skin compositions that can be used for cosmetic or skin treatment applications. In particular, topical skin compositions of the present invention can be designed to produce a localized surface plasmon resonance (LSPR) in response to indoor lighting conditions and / or outdoor lighting conditions. The produced LSPR can be beneficial to skin (e.g., reducing anti-oxidants or free-radicals that can cause oxidative damage to skin cells).B. Description of Related Art[0003]The use of plasmonic noble metal nanostructures in the cosmetics field is well-known. See WO 2012 / 027728 to Harris et al. Such structures have a plasmonic effect by producing a LSPR when subjected to electrom...

Claims

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Application Information

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IPC IPC(8): A61K8/19A61N5/06
CPCA61K8/19A61N5/062A61K2800/81A61K2800/413A61N2005/0657A61N2005/0651A61N2005/0655A61N2005/0654A61N2005/067A61Q19/00A61N5/067
Inventor WANG, HELIYIN, GUANGJUNODEH, IHAB N.
Owner SABIC GLOBAL TECH BV
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