Antimicrobial alginate fiber, and preparation method for and use of dressing thereof

Abstract

The present disclosure provides an antimicrobial alginate fiber, a method for manufacturing an antimicrobial alginate fiber dressing thereof, and an application thereof. When the cationic polymer polyhexamethylene guanide salt is mixed with the anionic polymer alginate, the antimicrobial activity of the guanide salt is quickly passivated. The present disclosure achieves a lower content of polyhexamethylene guanide salt in an alginate dressing with good long-term antimicrobial activities. The polyhexamethylene guanide salt has a low dissolution rate, and significantly reduces a potential risk of carcinogenicity, mutagenicity and reproductive toxicity.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation-in-part of International (PCT) Patent Application No. PCT / CN2017 / 094221, filed on Jul. 25, 2017, the entire contents of which are hereby incorporated by reference.TECHNICAL FIELD[0002]The described embodiments relate to a medical field of wound care or wound healing; and more particularly, to a manufacturing method and application of an antimicrobial alginate fiber and dressing materials thereof.BACKGROUND[0003]The alginate dressing may form a soft gel, after absorbing fluid exudating from a wound, providing an ideal moist environment for promoting wound healing and relieving wound pain. The alginate dressing has advantages of safety, non-toxicity, high hygroscopicity, hemostasis, gelation, and promoting wound healing, so that it is widely used in the field of wound care. However, the alginate dressing lacks antimicrobial properties.[0004]Because polyhexamethylene biguanide salt is highly cationic...

AI Technical Summary

Benefits of technology

This patent discusses another type of alginate dressing that has improved antimicrobial properties. This is achieved by combining the alginate with a compound called polyhexamethylene biguanide hydrochloride, which is a safe and effective antimicrobial agent. The dressing has good wound care properties such as safety, non-toxicity, high hygroscopicity, hemostasis, gelation, and promoting wound healing. The patent also introduces a new generation of antimicrobial dressings that use polyhexamethylene biguanide hydrochloride as an antimicrobial agent. Overall, this patent provides a solution for combining the characteristics of alginate and polyhexamethylene biguanide hydrochloride in a wound dressing.

Problems solved by technology

However, the alginate dressing lacks antimicrobial properties.

However, the polyhexamethylene biguanide salt has potential carcinogenicity, mutagenicity and reproductive toxicity at higher levels.

However, the chitosan itself is not a broad spectrum antimicrobial agent, and the antimicrobial activity can barely meet the expected requirement.

The medicine causes drug resistance and has other potential adverse side effects.

The antimicrobial alginate compound dressing has good anti-infectious effect, but a high level of honey is required, which increases manufacture cost.

A silver-containing alginate dressing is widely used in clinical practice, but when an organism absorbs silver, it causes toxicity and occurrence of drug-resistant microorganisms.

An in vitro cellular study discovered that, the silver-containing alginate dressing affects cell morphology of keratinocytes and fibroblasts, reduces fibroblast regeneration, and inhibits collagen synthesis in fibroblasts, so that the silver-containing alginate dressing hinders wound healing and produces sustained cytotoxicity.

Silver can enter body's cells to induce a potential risk of neurodegenerative diseases.

However, published literature show that nano-silver has some cytotoxicity.

The macromolecular polyguanidine is almost instantly dissolved in water, which is potentially highly risky.

An antimicrobial evaluation model in the patent is problematic.

In addition, the polyhexamethylene biguanide hydrochloride loaded on the alginate is highly soluble in water by the conventional soaking method, and the technique requires a high level of polyhexamethylene biguanide hydrochloride (0.5%-10%) to be added, which is highly risky.

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