Antimicrobial alginate fiber, and preparation method for and use of dressing thereof

Abstract

The present disclosure provides an antimicrobial alginate fiber, a method for manufacturing an antimicrobial alginate fiber dressing thereof, and an application thereof. When the cationic polymer polyhexamethylene guanide salt is mixed with the anionic polymer alginate, the antimicrobial activity of the guanide salt is quickly passivated. The present disclosure achieves a lower content of polyhexamethylene guanide salt in an alginate dressing with good long-term antimicrobial activities. The polyhexamethylene guanide salt has a low dissolution rate, and significantly reduces a potential risk of carcinogenicity, mutagenicity and reproductive toxicity.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation-in-part of International (PCT) Patent Application No. PCT / CN2017 / 094221, filed on Jul. 25, 2017, the entire contents of which are hereby incorporated by reference.TECHNICAL FIELD[0002]The described embodiments relate to a medical field of wound care or wound healing; and more particularly, to a manufacturing method and application of an antimicrobial alginate fiber and dressing materials thereof.BACKGROUND[0003]The alginate dressing may form a soft gel, after absorbing fluid exudating from a wound, providing an ideal moist environment for promoting wound healing and relieving wound pain. The alginate dressing has advantages of safety, non-toxicity, high hygroscopicity, hemostasis, gelation, and promoting wound healing, so that it is widely used in the field of wound care. However, the alginate dressing lacks antimicrobial properties.[0004]Because polyhexamethylene biguanide salt is highly cationic...

AI Technical Summary

Benefits of technology

[0037]Based on the above-mentioned reasons, by a large number of creative research experiments, it was discovered and confirmed for the first time that when the alginate fiber is loaded to polyhexamethylene biguanidine salt under an interface reaction with covalent bonding, the antimicrobial activity of the material is not passivated. Instead, the antimicrobial activity has a further improvement over the original activity. The polyhexamethylene biguanide salt, which is interfacial bonded with the alginate dressing, has almost no dissolution, and only a small amount of polyhexamethylene biguanide salt is dissoluted due to the dissolve of some of the alginate. The discovery of the present disclosure may provide a strong technical rationale for the development of a new generation of alginate antimicrobial dressings.

[0038]Applications of polyhexamethylene guanide salt in wound management are very mature and have been proven to positively promote wound healing and reduce pain, unpleasant smells and formation of carrion. The novel antimicrobial alginate dressing of the present disclosure is a polyhexamethylene guanide salt coating layer formed at the interface of alginate fibers. The novel antimicrobial alginate dressing of the prese

Problems solved by technology

However, the alginate dressing lacks antimicrobial properties.

However, the polyhexamethylene biguanide salt has potential carcinogenicity, mutagenicity and reproductive toxicity at higher levels.

However, the chitosan itself is not a broad spectrum antimicrobial agent, and the antimicrobial activity can barely meet the expected requirement.

The medicine causes drug resistance and has other potential adverse side effects.

The antimicrobial alginate compound dressing has good anti-infectious effect, but a high level of honey is required, which increases manufacture cost.

A silver-containing alginate dressing is widely used in clinical practice, but when an organism absorbs silver, it causes toxicity and occurrence of drug-resistant microorganisms.

An in vitro cellular study discovered that, the silver-containing alginate dressing affects

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