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Compositions and Methods for Cognitive, Immune and Digestive Support in Patients with Autism Spectrum Disorder

a technology for autism spectrum disorder and digestive support, applied in the direction of drug compositions, dispersed delivery, plant/algae/fungi/lichens ingredients, etc., can solve the problems of increased cancer risk, brain inflammation, pathologic changes, etc., to improve the quality of life, improve the effect of behavioral performance and improve the sign and symptoms

Pending Publication Date: 2021-05-06
FLAASK LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about improving the quality of life for subjects with autism spectrum disorder (ASD) and other immunocompromising conditions. It provides compositions and methods for modulating the immune system and improving the quality of life for these subjects by using natural ingredients. The invention includes an antiviral compound and a supplement composition that can improve the symptoms of ASD and viral infections simultaneously. Overall, the invention can help support immune health and improve the quality of life for these subjects.

Problems solved by technology

Additionally, individuals with ASD may experience pathologic changes such as brain inflammation, gastrointestinal problems, immune system imbalance, lipid metabolism imbalance, and possible increased risk of cancer due to links between autism and mutations in cancer-associated genes and pathways.
For some individuals, the core symptoms of ASD (i.e., impairments in communication and social interaction, and restricted / repetitive behaviors and interests) may improve with intervention and maturation; however, core deficits typically translate into varying developmental presentations that endure throughout the lifespan.
The exact cause of ASD development is not entirely clear, and the underlying root of ASD symptoms, such as damaged brain structures and impaired nerve connections, cannot be readily corrected by existing medications.
Identification of specific genetic risk variants has proved to be challenging, however, and many researchers suggest that there may be multiple pathways to the disorder, with prenatal and postnatal insult potentially contributing to its development in some instances.
For example, certain metabolic and other maternal conditions (e.g., diabetes, hypertension, obesity and infection), as well as consumption of alcohol and certain medications (e.g., antidepressants) during pregnancy may be associated with increased risk of ASD in offspring.
Additionally, maternal immune malfunction during pregnancy, including chronic immune activation of microglia, may also cause some alterations in a child's brain.
This might in turn disturb normal brain development.
The mechanism may also occur through immune responses in the mother while a fetus is developing, which may lead to weakening of the fetus's immune system and further lead to disturbances in brain development.
While this may produce short-term relief from certain cognitive and brain-related symptoms, it does not treat, for example, compromised immune health underlying a neurodegenerative condition.

Method used

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  • Compositions and Methods for Cognitive, Immune and Digestive Support in Patients with Autism Spectrum Disorder

Examples

Experimental program
Comparison scheme
Effect test

example 1

d Male “K. A.”

[0116]Prior to treatment, the child's parents reported that the child displayed the followed signs and symptoms of ASD: verbal delays; unclear speech or spoke only learned phrases; did not answer questions; could not express requests from others; exhibited some stereotypical movements with hands; did not play with children and toys or know how to join children's games; anger outbursts when he did not get what he wanted; anxiety; hyperactivity; frequent constipation; excessive sensitivity; hiding under his blanket; and sleep problems.

[0117]The initial test for the presence of infections revealed EBV IgG, CMV IgG, rubella IgG, and Helocobacter pylori IgG. The immune analysis showed the decreased level of T-helpers, T-lymphocytes, and IRI, and increased level of T-suppressors and NK cells. Blood analysis identified the increased level of erythrocytes and distribution of erythrocytes by volume.

[0118]After 1 month of the subject antiviral and supplement therapy, the parents...

example 2

ld Male “A. T.”

[0120]Prior to treatment, the child's parents reported that the child displayed the followed signs and symptoms of ASD: speech delays; repetition of certain words; unclear speech, only using separate words; poor understanding of speech; exhibited some stereotypical movements, including waiving of hands; difficulties making eye contact; could not play with children because they did not understand each other; and excessive focus on objects when he wanted them (repeating the name of the object until he got it and could not concentrate on anything else).

[0121]The initial test for the presence of infections revealed CMV IgG, HSV IgG, Mycoplasma IgG, EBV IgG, and Helicobacter Pylori IgG. Blood analysis identified the increased level of erythrocytes, hematocrit, amount of hemoglobin, and distribution of erythrocytes by volume.

[0122]After 1 month of the subject antiviral and supplement therapy, the parents reported the following changes: the child started to build sentences; ...

example 3

d Male “A. R.”

[0124]Prior to treatment, the child's parents reported that the child displayed the followed signs and symptoms of ASD: absence of speech (only one word in the vocabulary); stereotypical movements; excessive focus on numbers and letters; minor difficulties in communication with other children; aggressive behavior when he was not allowed to do what he wanted; hyperactivity; and frequent colds.

[0125]The test for the presence of infections revealed rubella IgG. The blood test showed the increased level of erythrocytes and hematocrit.

[0126]After 2 months of the subject antiviral and supplement treatment, the parents reported the following changes: the child started speaking with short sentences; he became more communicative, for example, saying when he wanted something; he started singing songs; there were 30 new words in his vocabulary; he started looking into people's eyes when speaking to them and tries to hold their hands; he became calmer; he cried less than previousl...

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Abstract

The present invention provides compositions and methods for improving the quality of life for a subject, particularly a child, diagnosed with autism spectrum disorder (ASD). In preferred embodiments, a supplement composition comprising natural or naturally-derived ingredients is delivered to a subject in the form of a chocolate bar or other candy alongside administration of an antiviral medication. Advantageously, the composition and methods can improve the immune health of the subject, along with other signs and symptoms associated with ASD, infections and other immunocompromising conditions.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority to U.S. Provisional Patent Application, Ser. No. 62 / 551,557, filed Aug. 29, 2017, which is incorporated herein by reference in its entirety.BACKGROUND OF INVENTION[0002]Autism spectrum disorder (ASD) refers to a group of neurodevelopment disorders, including autistic disorder (autism), Asperger syndrome, childhood disintegrative disorder, and pervasive developmental disorders, which are characterized by repetitive, distinctive patterns of behavior and difficulties with social communication and interaction. Subjects with ASD may have a combination of many symptoms and syndromes, which are typically present from early childhood and affect daily functioning.[0003]Included within ASD is a wide range of symptoms, skills, and levels of functional disability. Some children and adults with ASD are fully capable of performing all activities of daily life, while others require substantial support to perform basic lif...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/522A61K36/48A61K36/63A23L33/105A61K31/198A23L33/175A23L33/00A23L29/00A61P25/00
CPCA61K31/522A61K36/48A61K36/63A23L33/105A61P25/00A23L33/175A23L33/30A23L29/035A61K31/198A61K45/06A61K35/742A61K36/35A61K36/481A23L33/135A61P25/18A61P31/12A61K36/185A61K9/0056A61K9/0095A61K9/08A61K9/10A61K9/107A61K9/1605A61K9/2004A61K9/48A61K31/52A23V2002/00A61K2300/00A23V2200/31A23V2200/3204A23V2200/324A23V2250/063A23V2250/2104A23V2250/2116
Inventor LEFKOWITZ, ANDREW R.FARMER, SEANALIBEK, KENTSKHAY, ALBINAMOLDAKOZHAYEV, ALIBEK
Owner FLAASK LLC