Treatment of Female Genital Schistosomiasis
a female genital parasitic infection and treatment technology, applied in the field of tropical diseases, can solve the problems of increased mortality, less successful treatment of fgs, and increased risk of hiv infection, and achieve the effect of reducing the amount of adult worms
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example 1
[0029]Praziquantel powder (600 mg) was mixed with 2.5 g of K-YTM Jelly (Ingredients: Water, Glycerin, Hydroxyethylcellulose, Chlorhexidine, Gluconate, Gluconolactone, Methylparaben, Sodium Hydroxide.). A plastic vaginal applicator was loaded with the mixture for delivery to the subject. The mixture could include any vaginal lubrication as a medium, such as a jelly, gel, foam, or a liquid. Preferrably the medium is water soluble. The ingredients can be mixed by mechanical mixer or by hand to achieve a relatively homogeneous mixture.
example 2
[0030]Shistosomiasis is a blood-borne worm and generally resides in the circulatory system. We found that we are able to cure infected females with FGS of schistosomiasis in the blood but not the vaginal cavity.
[0031]A blood sample from a female with FGS was initially tested using Schisto POC-CCATM from ICT and confirmed to have a blood-borne infection of schistosomiasis. The female with FGS was then treated with three doses of 20 mg / kg oral praziquantel. After two weeks, blood of the female subject was retested and was found to be negative for schistosomiasis. However, observation of a vaginal sample from brushing with a swab was spread on microscope slides showed vaginal cells, fluid, blood, and live schistosomiasis worms still in the vagina.
[0032]A single dose of Praziquantel as described in Example 1 was vaginally inserted into the female subject. After two weeks, slides were observed under the microscope to be negative for schistosomiasis worms.
example 3
[0033]Praziquantel powder (1200 mg) is mixed with 20 ml normal saline (0.09% sodium chloride) and inserted using an intrauterine catheter. Mechanical or hand mixing of the ingredients is used to achieve a thorough combination of the ingredients, preferably dissolution.[0034]1. A unit dosage form of praziquantel, selected from the group consisting of:[0035]400-1000 mg praziquantel per 1.5-4.5 g vaginal vehicle;[0036]800-1500 mg praziquantel per 3-7 g vaginal vehicle;[0037]100-500 mg praziquantel per 1.5-4.5 g vaginal vehicle; or[0038]800-1500 mg praziquantel per 15-25 ml normal saline uterine vehicle.[0039]2. The unit dosage form of praziquantel of clause 1 wherein the vaginal vehicle is a cream, film, gel, or foam.[0040]3. A kit for locally treating female genital tissue infected with schistosomes, comprising:[0041]a vaginal applicator; and[0042]praziquantel.[0043]4. The kit of clause 3 further comprising a water soluble vehicle.[0044]5. The kit of clause 4 wherein the vaginal vechi...
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Abstract
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