Association between integration of viral as HPV or HIV genomes and the severity and/or clinical outcome of disorders as HPV associated cervical lesions or aids pathology

a technology of hpv and genome, applied in the field of viral and molecular biology, can solve the problems of insufficient, insufficient, and insufficient integration of hpv at this locus, and achieve the effects of reducing or eliminating episomal nucleic acid sequences, improving detection accuracy, and improving clinical outcomes
US20220064742A1Pending Publication Date: 2022-03-03GENOMIC VISION
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
GENOMIC VISION
Publication Date
2022-03-03

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Abstract

The invention concerns the detection and the quantification of integrated nucleic acids of viruses and thus the detection and follow-up of reservoir cells harbouring such integrated viral genomes. One aspect of the invention is directed to a method for detecting a level of integrated viral DNA that includes removing episomal viral or vector nucleic acids from genomic DNA in a cell sample, and quantifying a number of integrations of viral DNA into the genomic DNA of the cells by a method of amplification of an integration region in the DNA sample; thereby detecting a level of integrated viral DNA in the genomic DNA from a cell sample, such as a biological sample containing HPV virus and DNA.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application falls within a similar technical field as U.S. application Ser. No. 15 / 976,758 filed May 10, 2018 (or in WO2018 / 207022) and entitled Association between Integration of High-Risk HPV Genomes Detected by Molecular Combing and the Severity and / or Clinical Outcome of Cervical Lesions; Mahiet, et al., US 2016 / 0047006 A1, filed Mar. 4, 2015, entitled Diagnosis of Viral Infections by Detection of Genomic and Infectious Viral DNA by Molecular Combing; Lebofsky, et al., U.S. Pat. No. 7,985,542 B2, filed Sep. 7, 2006 entitled Genomic Morse Code; and Lebofsky, et al., U.S. Pat. No. 8,586,723 B2, filed Sep. 5, 2007 entitled Genomic Morse Code. Each of these documents is incorporated by reference in its entirety.BACKGROUND OF THE INVENTIONField of the Invention

[0002] The invention falls within the fields of virology and molecular biology, especially as applied to medical diagnostics, prognostics and therapy.Description of the Related A...

Claims

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