Novel peptide derived from pep27 peptide and uses thereof

a technology of pep27 and peptide, which is applied in the direction of peptides, peptides/protein ingredients, antibacterial agents, etc., can solve the problems of antibiotic treatment being less effective in clinical infections and bacteria's antibiotic resistance, and achieve excellent antimicrobial activity and low cytotoxicity

Pending Publication Date: 2022-08-04
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0018]The peptide of the present invention has excellent antimicrobial activity and low cytotoxicity, whereby it can be usefully used as an active ingredient of antibiotics, cosmetic compositions, food additives, feed additives, biological pesticides, quasi-drugs and the like.

Problems solved by technology

Unfortunately, the abuse of antibiotics has resulted in antibiotic resistance of bacteria.
The reason is that, if it is impossible to eradicate tolerant bacteria, antibiotic treatment would be less effective in clinical infections.

Method used

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  • Novel peptide derived from pep27 peptide and uses thereof
  • Novel peptide derived from pep27 peptide and uses thereof
  • Novel peptide derived from pep27 peptide and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparative Preparation of Pharmaceutical Formulation

[0173]1-1. Preparation of Powder

TABLE 10ComponentWeight (mg)Peptide of the present20 mginventionLactose20 mg

[0174]After admixing the above components, the mixture was filled in an airtight cloth bag to prepare powder.

[0175]1-2. Preparation of Tablets

ComponentWeight (mg)Peptide of the present 10 mginventionCorn starch100 mgLactose100 mgMagnesium stearate 2 mg

[0176]After admixing the above components, the mixture was punched to form a tablet formulation according to the conventional tablet formation method.

[0177]1-3. Preparation of Capsules

TABLE 12ComponentWeight (mg)Peptide of the present  10 mginventionCrystalline cellulose  3 mgLactose14.8 mgMagnesium stearate 0.2 mg

[0178]After admixing the above components, the mixture was charged in a gelatin capsule to form a capsule formulation according to the conventional capsule preparation method.

[0179]1-4. Preparation of Liquid Formulation

TABLE 13ComponentWeight (mg)Peptide of the prese...

example 2

Preparative Preparation of Cosmetics

[0183]2-1. Emollient Lotion (Skin)

[0184]In order to prepare an antimicrobial emollient skin lotion containing the peptide of the present invention, the following components could be admixed as listed in Table 15 below to prepare the emollient skin lotion according to the conventional manufacturing method in the field of cosmetics.

TABLE 15ComponentContent (wt. %)Peptide of the present0.1 to 30invention1,3-butyleneglycol3.0Glycerin5.0Polyoxyethylene (60)0.2hydrogenated castor oilEthanol8.0Citric acid0.02Sodium citrate0.06PreservativeTrace amountFlavorTrace amountPurified waterTo 100

[0185]2-2. Nutritional Lotion (Lotion)

[0186]In order to prepare an antimicrobial nutritional lotion containing the peptide of the present invention, the following components could be admixed as listed in Table 16 below to prepare the nutritional lotion according to the conventional manufacturing method in the field of cosmetics.

TABLE 16ComponentContent (wt. %)Peptide of ...

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Abstract

A peptide according to an embodiment of the present in which, in the amino acid sequence of SEQ ID NO: 1, (i) 2nd and 4th amino acids are each substituted with tryptophan (W); (ii) 2nd, 4th, 11st and 13rd amino acids are each substituted with tryptophan; and (iii) 2nd, 4th, 19th, 20th, 22nd, 23rd, 26th and 27th amino acids are each substituted with tryptophan. The peptide can be usefully applied as an active ingredient for antibiotics, cosmetic compositions, food additives, feed additives, biological pesticides and quasi-drugs.

Description

[0001]CROSS-REFERENCE TO RELATED APPLICATION AND CLAIM OF PRIORITY[0002]This application claims priority to Korean Patent Application No. 10-2021-0014180 filed on Feb. 1, 2021 in the Korean Intellectual Property Office (KIPO), the entire disclosure of which is incorporated by reference herein.BACKGROUND1. Field of the Invention[0003]The present invention relates to a novel peptide derived from PEP27 peptide and uses thereof.2. Description of the Related Art[0004]Bacterial infections are one of the most common and fatal causes of human disease. Unfortunately, the abuse of antibiotics has resulted in antibiotic resistance of bacteria. Indeed, a rate at which bacteria become resistant to new antibiotics is much faster than a rate at which analogs of new antibiotics are developed. For example, bacterial species such as Enterococcus faecalis, Mycobacterium tuberculosis and Pseudomonas aeruginosa, which possibly threaten human life, have developed resistance to all antibiotics known to da...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K14/315A61P31/04A61K8/64A61Q19/00A61Q19/10A23L33/18A23K20/147
CPCC07K14/3156A61P31/04A61K8/64A61K38/00A61Q19/10A23L33/18A23K20/147A61Q19/007Y02A50/30A23K20/195C12R2001/46A61Q17/005A01N63/50A61Q19/00A23L3/3571A23V2002/00
Inventor PARK, YOON KYUNGKANG, HEE KYOUNG
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