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Hydrophobic valve

a technology of hydrophobic valves and valve details, applied in the direction of valve details, slide valves, material analysis, etc., can solve the problems of contaminating samples, affecting the flow of liquids, and affecting the quality of samples,

Active Publication Date: 2013-05-14
SIEMENS HEALTHINEERS NEDERLAND BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a hydrophobic valve for liquids in a microfluidic device without the need for heat or contamination of samples. The valve can be opened and closed repeatedly, and is suitable for controlling liquid flow and dispersion in the device. The valve is made using a special process that allows for precise placement of magnetic particles, and can be used in a variety of microfluidic devices. The technical effects of the invention include improved control of liquid flow and dispersion, as well as reduced manufacturing problems and contamination of samples.

Problems solved by technology

However, control of liquid flow and / or liquid dispersion is still a problem in lab on a chip devices, due to manufacturing problems, as well as lack of controllability of behaviour of liquids in the micro- and nano scale.
Such valve however requires the use of heat, while the molten paraffin may contaminate the samples located on the device, or clog microchannels on the device.

Method used

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Examples

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Effect test

example 1

[0155]Experiments have been done with two kinds of devices. Both devices consist of a first solid substrate and a second solid substrate, which are separated from one another by a spacer (in this case by double sided adhesive tape of 100 μm thickness). The first solid substrate has a patterned surface comprising at least two hydrophilic areas separated from one another by at least one hydrophobic area.

[0156]In device 1, the second solid substrate has a hydrophobic surface, while in device 2, the second solid substrate has a hydrophilic surface.

[0157]The first solid substrate of both devices is a microscope glass slide on which a self-assembled monolayer (SAM) of perfluorodecyl-tri-etoxysilane is applied. This SAM is partly removed by oxygen plasma treatment, leaving a pattern of hydrophilic chambers as islands in a hydrophobic background. For device 1, the second solid substrate is a slide of PMMA that has been dipcoated in Teflon AF 1600. For device 2, the second solid substrate is...

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Abstract

The present invention relates to a hydrophobic valve for liquids having an appreciable surface tension comprising magnetic particles, said device comprising at least two planar solid substrates with a functionalized surface each, wherein at least a first solid substrate has a patterned surface comprising at least two hydrophilic areas separated from one another by at least one hydrophobic area, wherein the said two planar substrates are disposed with a distance to one another in a sandwiched, parallel fashion, in such way that said functionalized surfaces are facing one another, said valve further comprising a magnetic actuator.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a hydrophobic valve on a microfluidic device.BACKGROUND OF THE INVENTION[0002]In the last decades, miniaturized sample preparation and analysis units, so called “lab-on-a-chip (LOC)”, were introduced. These devices integrate one or several laboratory functions on a single chip of only millimeters to a few square centimeters in size. Their introduction was, at least in part, motivated by the introduction of nucleic acid hybridization technologies for diagnostic, analytic and forensic purposes, and by the increasing demand for high throughput capacities, which were necessitated by increasingly large sample numbers. The development of these devices has been supported by advancements in lithography-based technologies, as well as by new developments in surface coating technologies.[0003]However, control of liquid flow and / or liquid dispersion is still a problem in lab on a chip devices, due to manufacturing problems, as well as...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): B01L99/00
CPCB01F13/0809F16K99/0001F16K99/0021F16K99/0046B01L3/502738Y10T436/2575B01L3/502792B01L2200/027B01L2200/0647B01L2300/0816B01L2300/089B01L2300/161B01L2400/0406B01L2400/043B01L2400/0633B01L2400/0688B01L2400/088F16K2099/0074Y10T137/0324F16K99/0017F16K2099/0084B01F33/451
Inventor DEN DULK, REMCO CHRISTIAANPRINS, MENNO WILLEM JOSE
Owner SIEMENS HEALTHINEERS NEDERLAND BV