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Vegetable extract and method of use as an active principle in the production of a pharmacologically active product for the treatment of tissue lesions, and method for obtaining the extract

a vegetable extract and active principle technology, applied in the field of medicine, can solve the problem that the medical literature does not mention the use of products based on vegetable extracts

Active Publication Date: 2014-05-06
SAINZ PRESTEL VALERIA LUCILA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The resin extract effectively promotes tissue regeneration, reduces pain and inflammation, exhibits antimicrobial properties, stimulates bone growth, and is bioabsorbable, demonstrating potent analgesic, anti-inflammatory, and regenerative effects in clinical and preclinical trials.

Problems solved by technology

However, no mention is found in the medical literature of the use of products based on vegetable extracts that have demonstrated activity in the cleaning and healing of lesions that involve destruction of bone tissue.
However, to date there has not been any description of the use of extracts of Ficus pertusa L. f nor of Ficus eximia Schott, species endemic to Central America and South America, applied in the treatment of acute infectious lesions that cause extensive soft tissue necrosis, such as occurs in cases of synergistic necrotizing cellulitis, gangrene, pressure ulcers or in cases of enterocutaneous fistulas.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

case 1

[0027]

[0028]Woman of 17 years, who had a vestibular abscess in tooth 4 / 6, with grade II mobility. Radiologically, deep resinous filling, with furcal and distal periapical lesion. Root canal treatment was begun on Feb. 19, 2001 with 150 mg of resin extract of Ficus pertusa, which was deposited using a lentulo in the root canal in its third proximal to the pulp chamber. Progress was favorable and 11 days after the first application, with the tooth fixed and asymptomatic, check-up radiography showed furcal and periapical cortical regeneration. After five applications the tooth was filled definitively on Mar. 16, 2001. At the last check-up nine-and-a-half years later, she remained clinically asymptomatic and radiologically lesion-free.

case 2

[0029]

[0030]Man of 52 years, with a jacket with porcelain crown on tooth 4 / 5 and history of previous apicectomy with retrograde treatment. On Oct. 16, 2007, he had acute pain, and radiography showed a chronic periapical process. As it was impossible to withdraw the intraroot pin, a small hole was made directly above the periapical process, through which a small fragment of collagen sponge soaked in 200 mg of resin extract of the genus Ficus, species Eximia Schott, diluted in 1 cc of sterile distilled water, was introduced. It was not combined with systemic medication. At a check-up after 48 hours, the subject reported being asymptomatic and having been pain-free since the procedure described was performed. Being asymptomatic, radiography a month later showed disappearance of the radiolucent area.

case 3

[0031]

[0032]Woman of 35 years, after extraction of tooth 2 / 4 presented alveolitis sicca, having received as treatment multiple periosteotomies of the cavity, combined with antibiotics and anti-inflammatories, the latter giving rise to drug-induced gastritis. On Dec. 20, 2004, as the subject had acute pain, the resin extract of the genus Ficus was administered as 50% / 50% mixture of the species Ficus pertusa and Ficus eximia. The treatment consisted of depositing a fragment of collagen sponge soaked in 200 mg of extract diluted in 1 cc of sterile distilled water in the alveolar cavity and primary closure of the gum. Starting from this moment the subject had relief of symptoms. Radiography eighteen months after the treatment showed bone regeneration with conservation of the space, without bone retraction.

Examples Illustrating Application of the Invention, Other Types of Bone Lesions

[0033]The extract can also be applied in cases of osteomyelitis of bones of any type, and for this, in pa...

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Abstract

A resin extract from the Ficus pertusa L.f and / or Ficus eximia Schott tree and method of use as an active principle in the production of a pharmacologically active product for the treatment of acute and / or chronic tissue lesions in both bone tissue and soft tissue. A method for obtaining the extract is also disclosed.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application is the U.S. national phase of PCT Application No. PCT / ES2012 / 000032 filed on Feb. 16, 2012, which claims priority to Spanish Patent Application No. P201100167 filed on Feb. 16, 2011, the disclosures of which are incorporated in their entirety by reference herein.FIELD OF TECHNOLOGY[0002]The invention relates to the area of medicine, more concretely to the treatment of infectious and traumatic processes and of tissue lesions in general.PRIOR ART[0003]At present, in the area of the treatment of tissue lesions, various methods and substances are being investigated and applied with the aim of achieving tissue regeneration, advances that are constantly evolving and on which considerable effort is being expended given the complex nature of the regeneration of tissues, especially those involved in infectious processes.[0004]In cases of treatment of processes that involve bone tissue, materials and methods are applied which, wheth...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A01N65/00
CPCB29C2045/7214B29K2105/253B29C45/162B29C45/33B29C45/0416B29C45/00B29C2045/4078A61K36/60B29C45/7207A61K36/00A61P19/00A61P19/04
Inventor SAINZ PRESTEL, VALERIA LUCILASAINZ GUTIERREZ, ADRIAN ALONSO
Owner SAINZ PRESTEL VALERIA LUCILA