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Oral Glutamine to reduce stomatitis

a glutamine and oral technology, applied in the field of oral glutamine to reduce stomatitis, can solve the problems of limiting and affecting the ability to swallow large quantities, so as to reduce the damage to the oropharyngeal mucosa from chemotherapy and minimize the damage

Inactive Publication Date: 2007-02-06
EISAI INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The invention provides a way to protect the mouth, pharynx, and nasal mucosal membranes from damage caused by chemotherapy and radiotherapy. By using a small amount of glutamine, which is a nutrient, it can be taken orally or nasally to prevent mucositis. The glutamine is compounded with other materials to make it taste better. This treatment can improve the quality of life for patients with stomatitis and make it easier for them to tolerate cancer treatments."

Problems solved by technology

When such patients develop stomatitis, it is often so painful that swallowing is nearly impossible.
The areas to be treated by the invention may exhibit extremely painful stomatitis, which limits the ability to swallow.
Since these patients are in such pain, swallowing large quantities of anything is out of the question.
Enteral feeding is possible for nutrients through tubes, but causes pain and discomfort.
Furthermore, tube feeding does not supply glutamine to the stomatitis-afflicted mucosa and in patients with thrombocytopenia increases the risk of nasopharyngeal, esophageal and gastric mucosal bleeding.

Method used

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  • Oral Glutamine to reduce stomatitis
  • Oral Glutamine to reduce stomatitis

Examples

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Effect test

example 1

[0022]Patients experiencing mucositis of the oropharynx following a course of chemotherapy were offered the opportunity to enter this study if no other clinical parameters precluded receiving the same chemotherapy doses during the next course of treatment. Patients entering the trial received the same chemotherapy regimen as during the previous treatment, but in addition received a suspension of L-glutamine, 2 g / m2 swish and swallow twice daily, from day one of chemotherapy for 28 days or for 4 days past the resolution of any post-chemotherapy mucositis. The suspension of glutamine was prepared by mixing 50 grams of L-glutamine (supplied as a crystalline powder of Ajinomoto U.S.A., Inc., Raleigh, N.C.), with 4 parts of ORA-Sweet (Paddock Laboratories, Minneapolis, Minn.), 2 parts ORA-Plus (Paddock), and 2 parts of water to yield a suspension of 500 mg / ml L-glutamine. The final suspension contained 500 mg / ml glutamine, 30% sucrose, 2.5% glycerin, 2.8% sorbitol, 0.04% citric acid, 0.3...

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Abstract

Glutamine is administered orally at a rate of about 4.5 g / m2 per day to treat oropharyngeal mucositis. This is administered to patients that experience or may develop oropharyngeal mucositis, especially those caused by chemotherapy or radiotherapy.

Description

[0001]This application is a division of Ser. No. 08 / 039,905 filed Mar. 3, 1993, now U.S. Pat. No. 5,438,075 issued Aug. 1, 1995.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]This invention relates to methods of treating oropharyngeal mucositis and other oral and nasal mucositis by oral or nasal administration of glutamine.[0004]2. Description of the Related Art[0005]Mucositis is a common limiting toxicity of cancer chemotherapy. While the term mucositis refers to inflammation of a mucous membrane, this term is often used synonymously with stomatitis to refer to inflammation of the oral mucosa. The strict definitions of stomatitis (inflammation of the oral mucosa), enteritis (inflammation of the intestines), and mucositis (inflammation of mucous membranes including any region of the alimentary canal) will be used to avoid confusion.[0006]Although often a result of the bolus administration of anti-neoplastic agents, gut toxicity may be even more common when some agen...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K31/195A61K31/505A61K31/70A61K38/04
CPCA61K31/195A61K31/505A61K31/70A61K38/04A61K2300/00
Inventor SKUBITZ, KEITH M.ANDERSON, PETER M.
Owner EISAI INC
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