The invention discloses an Al-Nb-Zr-Mo-Hf-B system high-entropy alloy with neutron poison characteristics, and belongs to the field of high-entropy alloy materials. The Al-Nb-Zr-Mo-Hf-B system high-entropy alloy is prepared from the following components in percentage by mass: 5-15% of aluminum, 20-30% of niobium, 37-60% of zirconium, 4.99-15% of molybdenum, 1-20% of hafnium and the balance of boron (0.01-2%) and inevitable impurities. Aiming at the bottleneck problems that a conventional refractory high-entropy alloy of a typical BCC structure, such as TaNbMoW and TaNbMoWV, contains a large amount of high-density metal elements, is high in alloy density, high in cost and poor in room-temperature plasticity, and is difficult to use as a structural material, and the situation that the research on the high-entropy alloy with neutron poison characteristics is not fully paid attention to in original research, the high-entropy alloy based on the Al-Nb-Zr-Mo-Hf-B system is provided, the special effect of the element B is fully considered, and therefore structural function integration of the high-entropy alloy is achieved.