8 results about "P-hydroxyphenylethanol" patented technology

The invention discloses a synthesis method of hydroxytyrosol. The synthesis method comprises the following steps: (1) reacting p-hydroxyphenethyl alcohol as shown in a formula 1 with a bromination reagent in ethyl acetate at 0-25 DEG C to generate p-hydroxybromophenethyl alcohol as shown in a formula 2; (2) under the protection of nitrogen, reacting p-hydroxybromophenethyl alcohol in an aqueous solution of alkali in the presence of a copper catalyst and a ligand at 80-100 DEG C to generate hydroxytyrosol as shown in a formula 3; the copper catalyst is cuprous bromide; the ligand is phenanthroline. The raw materials and solvents required by the synthesis method are cheap and easy to obtain, the operation process is convenient and easy to implement, the synthesis method is environment-friendly, the reactant yield is high, the quality is good, and the synthesis method is suitable for industrial large-scale production.

This invention relates to a method for preparing p-hydroxyphenylethanol A. Using *Solanum tuberosum* fruit as raw material, this invention prepares p-hydroxyphenylethanol A through methods such as ethanol extraction, organic solvent extraction, chromatography, and high-performance liquid chromatography. Further research has revealed that this compound has the effect of lowering blood sugar and treating cognitive and social impairments associated with diabetes, and therefore can be used to treat diabetes.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an ophthalmic sustained-release adhesive gel containing a copolymer and oleate and a preparation process. The preparation comprises a block copolymer, oleic acid p-hydroxyphenethyl alcohol ester, structured phospholipid, a mucous membrane adhesion and permeation enhancing synergist, an active drug and a plurality of functional auxiliary materials, the preparation method comprises the following steps: preparing a co-assembled dispersion and a drug suspension, constructing a gel matrix, mixing and integrating functional auxiliary materials in a stepped manner, performing intermittent ultrasonic treatment and programmed ripening to optimize a system, and finally sterilizing and sub-packaging. The preparation can be used for treating chronic eye diseases such as glaucoma and the like, and has the advantages of lasting and stable drug release, strong mucous membrane adhesive power, good cornea permeation effect and capability of giving consideration to both mechanical properties and long-term stability; in addition, the preparation method provided by the invention has the advantages of ordered steps and controllable process, can effectively avoid component agglomeration, ensures the uniformity and performance stability of the preparation, and is suitable for large-scale production.

The application belongs to the technical field of resin materials, and particularly relates to a preparation method of a tensile organic resin. The preparation method of the organic resin comprises the following steps: mixing epoxy resin, composite polyol, metal-organic framework material with a three-dimensional network structure and a curing agent, heating and curing to obtain the organic resin; the composite polyol comprises at least one of pentaerythritol, trimethylolpropane, p-hydroxybenzyl alcohol and p-hydroxyphenethyl alcohol. The organic resin takes epoxy resin as a main component, takes composite polyol as an auxiliary component, is modified by the metal-organic framework material with the three-dimensional network structure, is added with the curing agent, makes the epoxy resin and the composite polyol have a cross-linking and curing reaction, forms a stable three-dimensional space network structure together with the metal-organic framework material with the three-dimensional network structure, and thus the tensile strength of the organic resin is significantly improved, and the organic resin has good wear resistance.

The application relates to application of p-hydroxybenzaldehyde A in preparation of blood sugar reducing drugs. The p-hydroxybenzaldehyde A is prepared by adopting the methods of ethanol immersion, organic solvent extraction, chromatography and high performance liquid chromatography and the like with acid fruit as raw material. Further research finds that the compound has the effect of reducing blood sugar and can be used for treating diabetes.

The invention provides a preparation process of 2-(4-benzyloxyphenyl) ethanol, which comprises the following steps: uniformly stirring p-hydroxyphenethyl alcohol, benzyl chloride, potassium carbonate, a solvent and a catalyst, heating to 110-120 DEG C, carrying out reflux heat preservation for 2-3 hours, filtering potassium salts such as potassium carbonate after heat preservation is finished, cooling to a first temperature, filtering to remove potassium salts such as potassium carbonate, potassium chloride and the like, and drying to obtain 2-(4-benzyloxyphenyl) ethanol; and cooling the filtrate to a second temperature, stirring for 2 hours, carrying out suction filtration to obtain a wet product of 2-(4-benzyloxyphenyl) ethanol, and drying to obtain a finished product of 2-(4-benzyloxyphenyl) ethanol, and the chemical equation of the preparation reaction is shown in the specification.

The present application relates to p-hydroxyphenethyl alcohol A and its application. The p-hydroxyphenethyl alcohol A has the following structural formula. The present application takes the acron as raw material, adopts ethanol extraction, organic solvent extraction, chromatography, high performance liquid chromatography and other methods to prepare p-hydroxyphenethyl alcohol A. And further research finds that the compound has the effects of reducing blood sugar and treating diabetes cognitive impairment and social impairment, and can be used for treating diabetes.

The invention discloses a trichogrammatid attractant and its preparation method and application, and belongs to the technical field of insect attractants. It comprises the following components in parts by weight: 0.5-4 parts of oleic acid, 1-7 parts of stearic acid, 0.3-3 parts of dioctyl phthalate, 0.4-3 parts of n-tetracosane, 0.2-2 parts of palmitic acid and 0.2-2.2 parts of p-hydroxyphenylethanol. The trichogrammatid attractant provided by the present invention, wherein multiple ingredients are used together in a ratio to attract female bees for parasitism, the parasitic effect is significantly enhanced, and the parasitic rate is increased by more than 40%. The raw materials in the trichogrammatid attractant of the present invention are low in price and easy to use, and the parasitic efficiency of trichogrammatids can be improved, which is beneficial to protecting crop yield from being affected, reducing the use of pesticides and the loss of agricultural products.