Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for processing production raw materials of vinca alkaloid

A technology of vinca alkaloids and processing methods, which is applied in the direction of organic chemistry, can solve the problems of difficult industrial production of chemical synthesis methods, and achieve the effects of short production cycle, low comprehensive cost and good natural activity

Inactive Publication Date: 2007-12-26
NORTHEAST FORESTRY UNIVERSITY +1
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vinca contains nearly a hundred kinds of alkaloids, most of which are active, among them, vinblastine sulfate, but because the content of vinblastine in vinca is extremely low, it is difficult to realize industrial production by chemical synthesis methods. Therefore, finding high-content vinblastine Raw materials for the production of vinca alkaloids are crucial

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Freshly collected periwinkle flowers with a moisture content of 70-80% are placed in a blast chamber. Under the condition of a humidity of 75%, they are treated with 30 degrees hot air for 3 hours, and then they are placed in a storage tank. Soak the PEG6000 solution with a concentration of 20% for 10 hours. After washing off the PEG6000 solution, pass in clear water. The ultraviolet lamp is irradiated once every 30 minutes, and each irradiation is 5 minutes. There are 2 irradiations in total. The irradiation dose is 5W / m. 2 , While irradiating, use negative pressure 0.06~0.1MPa suction or positive pressure 0.1~0.6MPa suction method for stirring. The RP-HPLC method determined the content of vinblastine alkaloids in the raw materials at this time. The results showed that the content of vinblastine in the raw materials was increased by 5.6 times after this process, and the content of vincristine was increased by 2 times.

Embodiment 2

[0020] Put the periwinkle with 60% water content in the blast chamber, and put it in the 40 degree hot air for 4 hours under the humidity of 80%, then put it in the storage tank, use 15% concentration The PEG6000 solution is soaked for 12 hours, and the PEG6000 solution is washed away and then poured into clear water. The UV lamp is irradiated every 30 minutes, and each irradiation is 5 minutes, a total of 4 irradiations, the irradiation dose is 6W / m 2 , While irradiating, use negative pressure 0.06~0.1MPa suction or positive pressure 0.1~0.6MPa suction method for stirring. The RP-HPLC method determined the content of vinblastine alkaloids in the raw materials at this time, and the results showed that after this process, the content of vinblastine in the raw materials was increased by 3.8 times, and the content of vincristine was increased by 0.72 times.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The processing method of raw material for producing vinca alkaloid includes the following steps: placing frech vinca under the condition of flowing air whose humidity is 60%-90% and blowing temperature is 23 deg.C-53 deg.C, treating for 1-8 hr, then changing condition, placing raw material into a sealed storage tank, in the PEG (polyoxyethylene glycol) 6000 solution whose concentration is 5%-35% and temperature is 15 deg.C-30 deg.C forced treating for 5-20 hr, washing out PEG solution, adding pure water, using 205-405 nm wavelength UV light to make irradiation for 1-3 hr, irradiating once every 30 min, every irradiation time is 3-5 min, and irradiation dose is 4-10 w / sq.m, so that the production raw material of vinca alkaloid can be obtained.

Description

Technical field: [0001] The invention relates to a method for processing raw materials for the production of vinca alkaloids. Background technique: [0002] Vinblastine (VLB), also known as vinblastine, and its sulfate vinblastine sulfate, is a national essential drug, mainly used to treat Hodgkin’s disease and choriocarcinoma. At present, vinblastine floral alkaloids are generally extracted from the Apocynaceae plant Catharanthus roseus. Catharanthus roseus contains nearly a hundred kinds of alkaloids, most of which are active. Among them, vinblastine sulfate is very low in content of vinblastine in Catharanthus roseus. It is difficult to realize industrial production by chemical synthesis methods. Therefore, find high content alkaloids. The raw materials for the production of vinca alkaloids are very important. [0003] On March 12, 2003, the Patent Office of the State Intellectual Property Office of the People’s Republic of China published "Method for Large-scale Culture of Ca...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D519/04C07D471/18C07D471/16
Inventor 祖元刚罗猛牟璠松付玉杰赵文灏李庆勇祖柏实张宝友
Owner NORTHEAST FORESTRY UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com