Drop pill type eye drip fluid of chloramphenicol, and preparation method

A technology of chloramphenicol and eye drops, which is applied in the field of pharmaceuticals, can solve problems such as unstable quality of chloramphenicol eye drops, and achieve the effects of advanced and reliable production technology, extended validity period, and improved stability

Inactive Publication Date: 2008-02-20
山东光明药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the deficiencies in the prior art, the present invention provides a method that can effectively solve the problem of unstable quality of chloramphenicol eye drops, separate the main drug chloramphenicol from the buffer, and effectively avoid the hydrolysis of chloramphenicol in aqueous solution. , improve the stability of medicine, prolong the new chloramphenicol eye drop of medicine validity period and preparation method thereof

Method used

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  • Drop pill type eye drip fluid of chloramphenicol, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] a. Weighing the ingredients, first according to the weight ratio of the prescription, chloramphenicol 12.5g, medicinal polyethylene glycol (PEG) 43.75

[0015] g, borax 1.78g, boric acid 67.05g, ethylparaben 2.49g, water for injection 5Kg, each component is weighed and prepared through weighing device 1 respectively;

[0016] b. To prepare the medicinal liquid, put the medicinal polyethylene glycol in the chemical material tank 3, heat it to 80-85°C and completely dissolve it, then add chloramphenicol, and keep the constant temperature at 80-85°C, and turn on the agitator Stir evenly to become liquid medicine;

[0017] c, make drop pills, pour the uniformly melted medicinal liquid into the drop pill machine 4, drop it into the liquid paraffin medium of 5~10° C., and quickly form it into a main pill with a weight of 56.25 mg and a content of chloramphenicol of 12.5 mg. Pills;

[0018] d, dripping pill sealing, the main medicine dripping pill that will make is first put...

Embodiment 2

[0022] a, batching weighing, first by the weight ratio of medicament prescription, chloramphenicol 20.0g, medicinal polyethylene glycol 68.8g, borax 2.88g, boric acid 107.17g, ethylparaben 4.11g, water for injection 8Kg, to Each component is weighed and prepared by weighing device 1 respectively;

[0023] b. To prepare the medicinal liquid, put the medicinal polyethylene glycol in the chemical material tank 3, heat it to 80-85°C and completely dissolve it, then add chloramphenicol, and keep the constant temperature at 80-85°C, and turn on the agitator Stir evenly to become liquid medicine;

[0024] c, make drop pills, pour the uniformly melted medicinal liquid into the drop pill machine 4, drop it into the liquid paraffin medium of 5~10° C., and quickly form it into a main pill with a weight of 88.8 mg and a chloramphenicol content of 20.0 mg. Pills;

[0025] d, dripping pill sealing, the main medicine dripping pill that will make is first put into drying machine 5 to spin d...

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Abstract

A dripping pill of Chloromycetin eye drops for treating trachnoma, keratitis, conjunctivitis, eyelid inflammation, etc is proportionally prepared from polyethanediol as matrix and Chloromycetin. It is applied in conjunction with the buffer liquid prepared from borax, boric acid, hydroxyphenyl ethylether and the water for injection. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a medicine, in particular to a chloramphenicol eye drop and a manufacturing method thereof. Background technique [0002] With the increasing development of medical drugs and the continuous needs of human health, the technical requirements for drug development and production are also getting higher and higher. In the known technology, chloramphenicol eye drops are commonly used drugs for the treatment and prevention of eye diseases. Existing chloramphenicol eye drops are mainly the aqueous solution of chloramphenicol, or borax, boric acid, sodium hyaluronate, injection Buffer solution composed of water, etc., but due to the nature of chloramphenicol, it is easily hydrolyzed and unstable in aqueous solution, and impurities such as hydrolyzed products and photodegraded products are easily produced, so that the product has not reached the expiration date and the diol exceeds the standard, resulting in a decrease in the potency of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/165A61K9/20A61K47/34A61P27/02A61K47/10
Inventor 段玉新
Owner 山东光明药业有限公司
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