Ginkgolide B soft capsule and its preparing method
A ginkgolide and soft capsule preparation technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of high price, poor stability and low bioavailability of ginkgolide B
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0025] Preparation of the contents: Mix 1 g of ginkgolide B, 3.4 g of polyethylene glycol 400, 0.5 g of propylene glycol, and 1 g of polyethylene glycol 6000, heat to 80°C, stir and mix until uniform, keep warm for later use.
[0026] Preparation of the capsule shell: Take 2g of gelatin, appropriate amount of water, mix evenly; take another 0.6g of glycerin, mix evenly with appropriate amount of water, heat to 55°C and melt, add the prepared gelatin solution, heat to 55°C while stirring, mix evenly and After vacuuming, keep warm at 50°C for later use.
[0027] Preparation of soft capsules: the above-mentioned prepared contents and capsule shell materials are processed into soft capsules through a soft capsule machine, and then dried.
[0028] Adopt the soft capsule that above preparation method makes, with reference to Chinese Pharmacopoeia 2000 edition two appendices XIXC drug stability test guideline, do influence factor investigation experiment, investigation result is as f...
Embodiment 2
[0032] Preparation of the content: Take 1g of ginkgolide B, 3g of polyethylene glycol 400, 0.1g of meglumine, 0.5g of glycerin, and 0.5g of polyethylene glycol 6000, mix them, heat to 70°C, stir and mix until uniform, keep warm for later use.
[0033] Preparation of the capsule shell: Take 2g of gelatin and mix with 0.5ml of water; take another 1g of sorbitol and mix with appropriate amount of water, heat to 46°C and melt, add the prepared gelatin solution, heat to 50°C under stirring, mix well and After vacuuming, keep warm at 50°C for later use.
[0034] Preparation of soft capsules: the above-mentioned prepared contents and capsule shell materials are processed into soft capsules through a soft capsule machine, and then dried.
[0035] Adopt the soft capsule that above preparation method makes, with reference to Chinese Pharmacopoeia 2000 edition two appendices XIXC drug stability test guideline, do influence factor investigation experiment, investigation result is as follo...
Embodiment 3
[0039] Preparation of contents: Mix 1g of ginkgolide B, 1.8g of peanut oil, 1.8g of corn oil, 1.2g of lecithin, 0.5g of methylcellulose, and 0.1g of vitamin E, heat to 85°C, stir and mix until uniform, keep warm for later use .
[0040] Preparation of the capsule shell: Take 2g of gelatin and mix with 0.5ml of water; take another 1g of sorbitol and mix with appropriate amount of water, heat to 46°C and melt, add the prepared gelatin solution, heat to 50°C under stirring, mix well and After vacuuming, keep warm at 50°C for later use.
[0041] Preparation of soft capsules: the above-mentioned prepared contents and capsule shell materials are processed into soft capsules through a soft capsule machine, and then dried.
[0042] Adopt the soft capsule that above preparation method makes, with reference to Chinese Pharmacopoeia 2000 edition two appendices XIXC drug stability test guideline, do influence factor investigation experiment, investigation result is as follows:
[0043] ...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More