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Siji sanhuang new preparation and preparing method and application

A technology of four seasons three yellows and preparations, applied in pill delivery, antiviral agents, pharmaceutical formulations, etc., can solve the problems of large dosage and long disintegration time

Inactive Publication Date: 2008-07-02
叶耀良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are disadvantages such as large dosage and long disintegration time

Method used

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  • Siji sanhuang new preparation and preparing method and application
  • Siji sanhuang new preparation and preparing method and application
  • Siji sanhuang new preparation and preparing method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1: Preparation of Sijisanhuang Extract

[0083] Rhubarb is crushed into a 20-mesh coarse powder, 5 times the amount of 45% ethanol is added for percolation, the ethanol extract is concentrated under reduced pressure, dried to obtain a rhubarb extract dry cream, which is crushed to 80-mesh for later use;

[0084] Add 8 times of water to Cortex Phellodendron, Scutellaria, and Gardenia, decoct twice, 3 hours each time, combine the decoctions, concentrate under reduced pressure to a relative density of 1.20 (25°C), add ethanol until the alcohol content is 60%, and let stand for 24 hours , filtered, and the filtrate recovered ethanol, concentrated, dried, and crushed to 80 meshes for subsequent use;

[0085] The above two dry pastes are combined and mixed to obtain the medicinal material extract.

Embodiment 2

[0086] Embodiment 2: Preparation of Four Seasons Sanhuang Extract

[0087] Rhubarb is crushed into a 40-mesh coarse powder, 10 times the amount of 75% ethanol is added for percolation, the ethanol extract is concentrated under reduced pressure, dried to obtain a dry paste of rhubarb extract, which is crushed to 100 mesh for later use;

[0088] Add 12 times of water to Phellodendron Phellodendron, Scutellaria baicalensis, and Gardenia, decoct twice, 3 hours each time, combine the decoctions, concentrate under reduced pressure to a relative density of 1.28 (25°C), add ethanol until the alcohol content is 65%, and let stand for 24 hours , filtered, and the filtrate recovered ethanol, concentrated, dried, and pulverized to 100 mesh for subsequent use;

[0089] The above two dry pastes are combined and mixed to obtain the medicinal material extract.

Embodiment 3

[0090] Embodiment 3: Preparation of Four Seasons Sanhuang Extract

[0091] Rhubarb is crushed into a 60-mesh coarse powder, 15 times the amount of 95% ethanol is added for percolation, the ethanol extract is concentrated under reduced pressure, and dried to obtain a rhubarb extract dry paste, which is crushed to a 160-mesh for later use;

[0092] Add 16 times of water to Cortex Phellodendron, Scutellaria, and Gardenia, decoct twice, 3 hours each time, combine the decoctions, concentrate under reduced pressure to a relative density of 1.35 (25°C), add ethanol until the alcohol content is 70%, and let stand for 24 hours , filtered, and the filtrate recovered ethanol, concentrated, dried, and pulverized to 160 mesh for subsequent use;

[0093] The above two dry pastes are combined and mixed to obtain the medicinal material extract.

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Abstract

A Chinese medicine in the form of dispersing tablet and dripping pill for treating the diseases caused by influenza virus, respiratory syncytial virus, adenovirus, coxsackie virus B, Echo virus 11 and simple hepes virus is prepared from rhubarb, capejasmine fruit, scutellaria root and phellodendron bark. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a new Sijisanhuang preparation with improved medicinal efficacy and a preparation method. technical background [0002] The traditional Chinese medicine Four Seasons Sanhuang Pill is a water pan pill made from rhubarb, gardenia, cork, and baicalin. The original standard is included in the second volume of the drug standard of the Ministry of Health of the People's Republic of China. For the treatment of: mouth and nose sores, sore throat, toothache, dry mouth, dizziness, constipation, red and yellow urine. There are disadvantages such as large dosage and long disintegration time. [0003] Currently, ordinary coated tablets, capsules, and soft capsules are on the market one after another. With the continuous changes in the environment and the adaptability of human beings to drugs, people have higher requirements for the bioavailability and efficacy of traditional Chi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61P31/12A61K36/756A61K36/744A61K36/708A61K36/539A61P31/16A61P31/22
Inventor 叶耀良廖志钟
Owner 叶耀良
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