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Use of chloride 13-hexyl berberine in preparation of medicine for treating peptic ulcer and bacteriological gastroenteritis

A technology for Helicobacter pylori and peptic ulcer, which is applied in the field of application of 13-hexylberberine hydrochloride in the preparation of medicines for treating gastritis or peptic ulcer related to Helicobacter pylori, and can solve the problems of no experimental research reports, etc.

Inactive Publication Date: 2008-11-19
CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its mechanism of action may be related to anti-Hp, anti-inflammation, and participation in the regulation of inflammatory cytokines, but there is no experimental research report

Method used

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  • Use of chloride 13-hexyl berberine in preparation of medicine for treating peptic ulcer and bacteriological gastroenteritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment tablet

[0020] Weighing: HB-13 0.005g,

[0021] Microcrystalline cellulose (100 mesh) 0.025g

[0022] Starch (120 mesh) 0.008g

[0023] LU magnesium powder (100 mesh) 0.015g

[0024] Talc powder 0.008g

[0025] Magnesium stearate 0.004g

[0026] Mix the auxiliary materials, dry at 100°C for later use, then mix in the main ingredient HB-13, and press into tablets.

Embodiment 2

[0027] The preparation of embodiment two capsules

[0028] Weighing: HB-13 0.005g

[0029] Starch 0.20g

[0030] Lactose 0.05g

[0031] Fill the No. 4 capsule after mixing.

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PUM

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Abstract

The invention relates to a method for using alcaine 13-hexyl berberine to prepare the drug that treats gastritis enteritis caused by pylorus bacillus (Hp), etc. Wherein, alcaine 13-hexyl berberine is the derivate replaced by replacing the thirteenth -H with hexyl -C6H13 in parent compound alcaine berberine, its MIC resistant to pylorus bacillus is 2 mug / ml, and anti-inflammatory cell factor is IC505-10 mug / ml. It has stronger activity then alcaine berberine. And it can be made into oral tablet and capsule.

Description

technical field [0001] The invention relates to the preparation and application of compound 13-hexylberberine hydrochloride (HB-13 for short) to treat gastritis or peptic ulcer related to Helicobacter pylori (Hp). Background technique [0002] According to modern etiology, Hp infection is the main cause of chronic gastritis and peptic ulcer. The human gastric mucosa is the natural colonization site of Hp, which mainly adheres to the mucus layer. Therefore, the use of anti-Hp drugs is an important and key measure in the treatment of gastritis, gastric and duodenal peptic ulcer. [0003] In addition to anti-Hp infection drugs, the current main drugs for the treatment of gastritis and peptic ulcer include antacid and antacid secretion drugs, gastric mucosal protective drugs, and gastric motility promoting drugs. Among them, most anti-Hp drugs have a high clearance rate of Hp, but a low eradication rate. The combination method can improve the eradication rate, but the rate and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61K9/20A61K9/48A61P1/12A61P31/04
Inventor 郑家润张崇璞李耐三李新宇唐美育高纪伟徐兰芳
Owner CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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