Targeted, control-release and thin film coating material made of denatured starch for oral medicine to treat colonic diseases, its prepn. and use

A film coating material, modified starch technology, applied in the directions of pharmaceutical formulations, drug delivery, etc., can solve the problems of incomplete release of active functional ingredients, leakage of active functional ingredients, lack of controlled release speed of active functional ingredients, etc., and achieve good application prospects. , Fast release rate, good social and economic benefits

Active Publication Date: 2009-07-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the lack of related coating carrier materials in the current oral colon-targeted controlled release system and the slow controlled release rate of the active functional ingredients by the coating carrier materials in the existing research, the leakage of the active functional ingredients in the upper gastrointestinal tract cannot be avoided and the activity of the active functional ingredients cannot be avoided. Due to the incomplete release of functional components, the primary purpose of the present invention is to provide a modified starch oral colon targeting controlled release film coating material

Method used

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  • Targeted, control-release and thin film coating material made of denatured starch for oral medicine to treat colonic diseases, its prepn. and use
  • Targeted, control-release and thin film coating material made of denatured starch for oral medicine to treat colonic diseases, its prepn. and use
  • Targeted, control-release and thin film coating material made of denatured starch for oral medicine to treat colonic diseases, its prepn. and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Utilize acetate starch (prepared in the laboratory, the preparation method refers to "Research on the Digestibility of Drug Controlled Release Carrier Acetate Starch" Li Xiaoxi et al., Functional Polymers, 2003, (4)) to prepare oral colon-targeted controlled-release film coating materials, Including the following steps:

[0028] (1) Preparation of oral colon-targeted controlled-release film coating solution of acetate starch:

[0029] Add 0.6 g of starch acetate with a degree of substitution of 1.0, 2.02 and 2.70 into 20 ml of acetone solution to form an acetone solution containing 3% starch acetate by mass, then add 10% starch acetate by mass, 15% and 35% of the plasticizer dibutyl sebacate, namely to obtain the oral colon-targeting controlled-release film coating liquid of acetate starch (ie, the oral colon-targeted controlled-release film coating material of acetate starch).

[0030] (2) Establishment of oral colon-targeted controlled-release film coating system of ...

Embodiment 2

[0037] Utilize starch phosphate (laboratory system, preparation method is referred to " the optimization of the preparation condition of monoester of sweet potato starch phosphate " Chen Ling etc., Zhengzhou Institute of Technology Journal, 2004 (1)) prepares oral colon targeting controlled release film coating material, comprises Follow the steps below:

[0038] (1) Preparation of oral colon-targeted controlled-release film coating solution of ester starch:

[0039] Add 0.4 g of phosphate starch with degrees of substitution of 1.0, 1.58 and 2.4 into 20ml of deionized water, heat at 80°C for 10 minutes, and make suspensions containing 2% phosphate starch by mass, and then add the same amount Glycerol which is 15% of the mass of starch phosphate is formulated into starch phosphate oral colon-targeting controlled-release film coating liquid (ie, starch phosphate oral colon-targeted controlled-release film coating material).

[0040] (2) Establishment of phosphate starch oral co...

Embodiment 3

[0047] Utilize xanthate starch (laboratory system, preparation method refers to "modified starch" Zhang Zhangtian, South China University of Technology Press, 1992) to prepare oral colon targeting controlled release film coating material, comprising the following steps:

[0048] (1) Preparation of xanthate starch oral colon-targeted controlled-release film coating solution:

[0049] Add 0.6 g of xanthate starches with degrees of substitution of 1.13, 1.82 and 2.60 into 20 ml of deionized water, heat at 80°C for 10 minutes, and prepare a suspension containing 4% xanthate starch by mass , and then add the glycerin that consumption is xanthate starch quality 15%, 18% and 20% respectively, namely be made into different xanthate starch oral colon targeting controlled-release film-coating solutions (being xanthate starch Oral colon targeting controlled release film coating material).

[0050] (2) Establishment of xanthate starch oral colon-targeted controlled-release film coating s...

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Abstract

A release controllable film coating material targetting to colon is prepared from modified starch through adding the modified starch to coating solvent, and adding plasticizer. Its application is also disclosed.

Description

technical field [0001] The invention relates to a film coating material, in particular to a modified starch oral colon targeting controlled release film coating material and its preparation method and application. Background technique [0002] Oral colon-targeted controlled release system is to select appropriate carrier materials and controlled release technology to deliver the active functional ingredients to the ileocecal part of the human body, disintegrate or release the active ingredient particles, and then release the particles wrapped in them at a suitable speed. The active ingredients inside have the effect of increasing the local concentration and bioavailability of the active ingredients. The colon-targeted controlled-release system can protect functional ingredients that are easily destroyed by gastric acid or metabolized by pancreatic enzymes, especially to avoid the inactivation of peptides and protein biomacromolecules in the upper digestive tract and increase...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K9/00A61K9/22A61K9/52
Inventor 李晓玺陈玲李琳李冰张喜梅
Owner SOUTH CHINA UNIV OF TECH
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