Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Quality control method of bone sinew medicinal pill preparation

A detection method, the technology of Gujin Wan, which is applied in the field of quality control of medicines and Gujin Wan preparations, can solve problems such as backward quality control standards, difficult product quality control, and inability to effectively control the quality of Gujin Wan preparations.

Inactive Publication Date: 2009-07-29
GUIZHOU YIBAI PHARMA CO LTD
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, "Gujinwan Capsules" and "Gujinwan Tablets" are recorded in the thirteenth volume of traditional Chinese medicine prescriptions issued by the Ministry. This medicine has been used clinically for many years. , proliferative arthritis, Kashin-Beck disease and other diseases have achieved relatively satisfactory therapeutic effects, but our research found that the existing Gujin Wan preparations have the disadvantages of simple and backward quality control standards and difficult product quality control
Since Radix Paeoniae Alba, Panax notoginseng, Corydalis Corydalis, Duhuo, Gentiana chinensis, and Nuxychnoma are all drugs that play a major role in the preparation of Gujin pills, Nuxynum is also a toxic medicinal material, and only alkaloid medicinal materials are included in the existing quality standards for preparations. The color reaction identification was carried out with Duhuo medicinal materials, and no content determination or identification research was carried out on other medicinal materials. Therefore, the existing quality control methods cannot effectively control the quality of Gujin Wan preparations, which will affect the production and quality assurance of products.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quality control method of bone sinew medicinal pill preparation
  • Quality control method of bone sinew medicinal pill preparation
  • Quality control method of bone sinew medicinal pill preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Quality control methods for Gujinwan capsules, tablets or granules.

[0112] To observe the traits, the steps are;

[0113] For capsules: the contents are brown; smell, bitter and astringent;

[0114] For tablets; the drug is brown; smell, bitter, astringent;

[0115] For granules: the product is brown granules;

[0116] To identify the contents, the steps are:

[0117] (1) Take capsules, tablets or granules respectively and observe under a microscope: gelatinized starch granules are light yellow or nearly colorless; hypodermal sclerenchyma cells are green and yellow, and the cells are polygonal, square or long. , the wall is slightly curved, lignified, some become beaded and thickened, and the pits are fine; the stone cells are light yellow, sub-round or oblong, with a diameter of about 60 μm, the wall is thicker, and the pits are fine; the diameter of the threaded vessel is 16 ~32μm; many starch granules, single round, semicircular or round polygonal, 4~30μm in di...

Embodiment 2

[0127] To observe the traits, the steps are:

[0128] For capsules: the contents are brown; smell, bitter and astringent;

[0129] For tablets: the drug is brown; the smell is bitter and astringent;

[0130] For granules: the product is brown granules;

[0131] To identify the contents, the steps are:

[0132] (1) Take capsules, tablets or granules respectively and observe under a microscope: gelatinized starch granules are light yellow or nearly colorless; hypodermal sclerenchyma cells are green and yellow, and the cells are polygonal, square or long. , the wall is slightly curved, lignified, some become beaded and thickened, and the pits are fine; the stone cells are light yellow, sub-round or oblong, with a diameter of about 60 μm, the wall is thicker, and the pits are fine; the diameter of the threaded vessel is 16 ~32μm; many starch granules, single round, semicircular or round polygonal, 4~30μm in diameter; compound grains are composed of more than 2~10 sub-grains; re...

Embodiment 3

[0143] To observe the traits, the steps are:

[0144] For capsules: the contents are brown; smell, bitter and astringent;

[0145] For tablets: the drug is brown; the smell is bitter and astringent;

[0146] For granules: the product is brown granules;

[0147] To identify the contents, the steps are:

[0148] (1) Take capsules, tablets or granules respectively and observe under a microscope: gelatinized starch granules are light yellow or nearly colorless; hypodermal sclerenchyma cells are green and yellow, and the cells are polygonal, square or long. , the wall is slightly curved, lignified, some become beaded and thickened, and the pits are fine; the stone cells are light yellow, sub-round or oblong, with a diameter of about 60 μm, the wall is thicker, and the pits are fine; the diameter of the threaded vessel is 16 ~32μm; many starch granules, single round, semicircular or round polygonal, 4~30μm in diameter; compound grains are composed of more than 2~10 sub-grains; re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a quality control method of Gujin pill preparation. The method uses thin-layer chromatography to identify licorice, motherwort and Xu Changqing, and uses high-performance liquid chromatography to measure the content of glycyrrhizic acid. The quality control method has good precision, sensitivity and stability, ensuring the safety, uniformity, stability, effectiveness and controllability of the product quality.

Description

Technical field: [0001] The invention relates to a quality control method of Gujin Wan preparation, which belongs to the field of pharmaceutical technology. technical background: [0002] Hypertrophic spondylitis, cervical spondylosis is a common disease that endangers the health of people today. [0003] Gujin Wan preparation is composed of frankincense, myrrh, white peony root, corydalis (made from vinegar), notoginseng, woody, safflower, turmeric, solitary life, achyranthes bidentata, gentiana, cassia twig, dried blood, and nux. Composed of fourteen herbs; it has the effects of promoting blood circulation and removing blood stasis, relaxing tendons and collaterals, dispelling wind and relieving pain, and is used to treat hypertrophic spondylitis, cervical spondylosis, heel spurs, hypertrophic arthritis, Kashin-Beck disease and other diseases. Among them, "Gujinwan Capsules" and "Gujinwan Tablets" are recorded in the thirteenth volume of traditional Chinese medicine presc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/90A61K36/9066A61K36/51A61K36/328A61K36/21A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P19/08G01N30/02G01N33/15
Inventor 叶湘武张梅
Owner GUIZHOU YIBAI PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com