The raw material medicine of Xiaoer Qingfei Huatan preparation is composed of eight traditional Chinese medicines such as ephedra, peucedanum, scutellaria baicalensis, perilla seed, gypsum, bitter almond, Tinglizi and Zhuru. In the existing quality control methods, the method of identifying its components has major defects, and there is even a lack of content determination of its components. In order to effectively control the quality of the preparation, we have established a new quality control method for Xiaoer Qingfei Huatan preparation , the method adopts thin-layer chromatography for identification, and high-performance liquid chromatography for content determination. The quality control method has good precision, sensitivity and stability, ensuring the product quality is "safe, uniform, stable, effective and controllable".