Process of extracting separating and purifying artemisinin from sweet wormwood herb

A technology for separation and purification of artemisinin, applied in the fields of plant/algae/fungus/moss components, plant raw materials, medical preparations containing active ingredients, etc., which can solve the problems of large solvent consumption, high extraction pressure, and long process time. , to achieve the effect of easy industrial scale, high output-price ratio and low extraction pressure

Inactive Publication Date: 2009-08-19
HUNAN KEYUAN BIO PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The shortcomings of this process are that the extraction and separation process is cumbersome, the amount of solvent used is large, the process takes a long time, and the silica gel column needs to be regenerated, which leads to an increase in the cost of extraction and separation.
However, the disadvantage of this process is that the extraction pressure is relatively high (10Mpa-20MPa)
Because the content of artemisinin in the raw material is about 0.4-0.8%, and the bulk density of the raw material of Artemisia annua is only about 0.25, therefore, if the extraction on an industrial scale is to be carried out, the volume of the equipment for supercritical carbon dioxide extraction needs to be large, and the high-pressure The price of equipment is generally much higher than that of low-voltage equipment, so the investment in equipment for this process is huge

Method used

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  • Process of extracting separating and purifying artemisinin from sweet wormwood herb

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] according to figure 1 The procedure is to weigh 1 kg of Artemisia annua raw material crushed to 40 mesh and with an artemisinin content of 0.6%, put it into a 5-liter extractor, and then inject butane into the extractor through a compressor, and set the extraction temperature and pressure respectively to Set at 25°C and 0.4Mpa; after stirring and extracting for 0.5 hours, the solvent (extract) containing the solute is transferred to the separator, and the solvent butane comes out of the separator and enters the solvent storage tank for the next cycle. The solute (extract) coming out from the separator enters the desolventizer, and obtains 31.0 grams of artemisinin extract after further desolventization. Then add 465 milliliters of 40% ethanol solution at a weight-to-volume ratio of 1:15, heat to dissolve at 60°C, heat filter to remove insoluble matter, then place the filtrate at room temperature, filter after needle-like crystals are precipitated, and filter to obtain ...

Embodiment 2

[0017] Weigh 1 kg of raw material of Artemisia annua crushed to 40 mesh and with an artemisinin content of 0.6%, put it into a 5-liter extractor, then inject butane into the extractor, and set the extraction temperature and pressure to 45°C and 0.6Mpa; after stirring and extracting for 1.0 hour, the extract (solvent + solute) is transferred to the separator, and the solvent butane comes out of the separator and enters the solvent storage tank for the next cycle. The extract that comes out from the separator enters the desolventizer, and obtains 34.0 grams of extract after further desolvation. Then add 340 ml of 55% ethanol solution at a weight-to-volume ratio of 1:10, heat to dissolve at 60°C, heat filter to remove insoluble matter, then place the filtrate at room temperature, and filter after needle-like crystals are precipitated. The obtained crystals were dissolved in absolute ethanol and then purified by recrystallization. The weight-to-volume ratio of crystals to absolute...

Embodiment 3

[0019] Weigh 1 kg of raw materials of Artemisia annua crushed to 40 mesh and with an artemisinin content of 0.6%, put it into a 5-liter extractor, then inject butane into the extractor, and set the extraction temperature and pressure to 65°C and 65°C respectively. 1.0Mpa; after stirring and extracting for 3.0 hours, the extract (solvent + solute) is transferred to the separator, and the solvent butane comes out of the separator and enters the solvent storage tank for the next cycle. The extract that comes out from the separator enters the desolventizer, and obtains 35.0 grams of extract after further desolvation. Then add 245 ml of 75% ethanol solution at a weight-to-volume ratio of 1:7, heat to dissolve at 60°C, heat filter to remove insoluble matter, then place the filtrate at room temperature, and filter after needle-like crystals are precipitated. The obtained crystals were dissolved in absolute ethanol and then purified by recrystallization. The weight-to-volume ratio of ...

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Abstract

The present invention is process of extracting, separating and purifying artemisinin from sweet wormwood herb. Artemisinin is first extracted from crushed sweet wormwood herb material with butane solvent in supercritical state inside an extractor at set extracting temperature and pressure. Inside a separator, the solute and the solvent are separated, the separated solvent is reused, and the solute is further solvent eliminated to obtain artemisinin. The extracted and separated artemisinin is re-crystallized in alcohol solution and anhydrous alcohol to obtain high purity artemisinin product. The present invention extracts artemisinin at low temperature and low pressure to avoid heat decomposition of artemisinin, and the post-treatment is simple and feasible.

Description

technical field [0001] The invention relates to a method for extracting, separating and purifying artemisinin from Artemisia annua plants, using Artemisia annua plants as raw materials, using butane as a solvent, selectively extracting artemisinin at low temperature and low pressure, and then purifying artemisinin by recrystallization element, which belongs to the field of natural product separation engineering. Background technique [0002] Artemisinin is a new type of antimalarial drug isolated from the plant Artemisia annua. It has the characteristics of low toxicity, high efficiency and quick action. It is replacing quinine and other therapeutic drugs and has become the main force in the fight against malaria. The international market is in short supply. According to the report of the World Health Organization, 2.7 million people die of malaria every year in the world. On June 6, 2005, the World Health Organization held the International Artemisinin Conference in Tanzani...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/18A61K36/282
CPCY02P20/54
Inventor 赵亚平邓良徐刚
Owner HUNAN KEYUAN BIO PRODS
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