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Dysmenorrhea treating solid medicine preparation and its preparation process
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A technology of solid preparations and drugs, applied in the field of drug solid preparations for treating dysmenorrhea and its preparation, to achieve the effects of overcoming easy caking, simple operation process, and accurate dosage
Inactive Publication Date: 2009-08-26
上海海虹实业(集团)巢湖今辰药业有限公司
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Abstract
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[0004] The technical problem to be solved by the present invention is to avoid the deficiencies in the above-mentioned prior art, and to provide a drugsolid preparation for treating dysmenorrhea, to overcome the adverse effects of the liquid preparation on the human body due to ethanol, preservatives and a large amount of sucrose, and to To achieve the purpose of stable preparation, uniform dispersion of active ingredients, convenient administration and accurate dosage
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Embodiment 1
[0017] Preparation of Yikunning Tablets
[0018] Weigh 90g of angelica, 60g of Cyperus cyperi, 15g of cassiabark, 60g of Rehmannia glutinosa, 60g of white peony, 60g of Chuanxiong, 60g of Motherwort, 30g of Corydalis Corydalis, 15g of trigonum, and 15g of orange peel.
[0019] The above ten flavors are crushed into coarse powder, according to the percolation method under the item of liquid extract and extract, use 45% ethanolsolvent, after immersion for 48 hours, slowly percolate at a speed of 1-3ml per minute, and collect the primary percolation The liquid is about 750ml, and the percolation is continued until the filtrate is nearly colorless, the first eluate is combined, and the filtrate is concentrated to a relative density of 1.06-1.12 (at 50° C.) to obtain a concentrated solution.
[0023] The preparation process is the same as in Example 1, except that the granules are filled into capsules to obtain 400 capsules.
Embodiment 3
[0025] Preparation of Yikunning Granules
[0026] The preparation process is the same as in Example 1, except that the added forming agent is 120 g of lacto-oligosaccharide, dry granulated (material temperature below 60° C.), and granulated to obtain 200 g of brown-yellow granules with slight gas and sweet taste. Fill into bags, 1g per bag, to get 200 bags of granules.
[0029] The spray drying efficiency of the liquid medicine is related to the concentration of the liquid medicine. According to Table 1, the relative density of the concentrated liquid is 1.06-1.12 (50°C) as the concentration end point.
[0032] About the effect of spray-dried powder on active ingredients
[0033] Spray drying under suitable conditions can completely retain the active ing...
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Abstract
Yikunning solid preparation and preparation method thereof, take Angelica root, Cyperusofficinalis, cinnamon bark, Rehmannia glutinosa, Baishao, Chuanxiong, Motherwort, CorydalisCorydalis, Sanleng and orange peel as raw materials, and it is characterized in that there is another molding agent; It is at least one of dextrin and oligosaccharide. It is also characterized in that the method of spray drying and dry granulation is adopted in the preparation process, which can completely retain the effective components and facilitate large-scale production under the condition of continuous GMP. The medicine does not contain ethanol, sucrose and preservatives, is safe to take without side effects, the active ingredients are uniformly dispersed, the medicine is stable, and has the advantages of convenient taking and accurate dosage.
Description
technical field [0001] The invention relates to a traditional Chinese medicine for treating blood deficiency and Qi stagnation, irregular menstruation, premenstrual and postmenstrual abdominal pain and lumbago, women's climacteric syndrome and a preparation method thereof. Background technique: [0002] With the acceleration of the pace of society and the increase of work pressure, irregular menstruation, premenstrual and menstrual abdominal pain have become common and frequently-occurring diseases in women. Modern chemical medicine lacks a safe, efficient and long-term medication for treating this type of disease. [0003] This type of traditional Chinese medicine preparation that has been available at present is a liquid tincture, the dosage form is backward, and the drug stability is poor; it contains preservatives and a large amount of sucrose, and the intake of preservatives and too much sugar is not good for the human body and affects the safe use of the preparation; ...
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