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Medicine reliesing micro electronic capsule

A microelectronics and drug release technology, which is applied in the directions of capsule delivery, drug delivery, and pharmaceutical formulations, can solve the problems of reduced drug release reliability, increased load on the driving mechanism, and hindered forward movement of the piston, and achieves a simple structure and improved reliability. The effect is conducive to mass production

Inactive Publication Date: 2009-09-02
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] According to the research of the inventor's research team, the current technology has the following problems in practical application: when the piston moves towards one end of the drug storage bin, the piston, the drive mechanism, and the closed chamber at one end of the control circuit will generate negative pressure. The less air there is, the greater the negative pressure will be. In order to save space, the airtight compartment often has just enough capacity for circuit devices, and the volume occupied by air is very small. According to calculations, the negative pressure generated by the closed compartment is relatively large. Negative pressure prevents the piston from moving forward, and the negative pressure gradually increases during the forward movement of the piston, generally speaking, it can reach 5-10 Newtons. In order to overcome the influence of negative pressure, the driving force of the driving mechanism must be strong enough , in the tiny space of miniature electronic capsules, the driving mechanism is generally a micro device, it is difficult to provide a strong enough driving force, and the spring with sufficient driving force must be fixed with a stronger material, which further increases the difficulty of manufacturing; in addition, the airtight Another problem with the negative pressure generated by the chamber is that if the piston is slightly less airtight, the negative pressure may suck the liquid medicine into the airtight chamber instead of releasing it into the digestive tract. This situation often occurs in the test, making the drug release more reliable. In order to improve the sealing reliability of the piston, the friction force between the piston and the piston wall generally needs to be increased, further increasing the load on the driving mechanism and further increasing the manufacturing difficulty of the system

Method used

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  • Medicine reliesing micro electronic capsule
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  • Medicine reliesing micro electronic capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The drug-releasing microelectronic capsule of the present embodiment includes a housing 1, a power supply mechanism 2, a control circuit 3, a piston 4, and a drug-release channel mechanism including a drug-releasing through hole 5 and a sealing plug 6, and the driving mechanism of the drug-releasing microelectronic capsule Comprising a micro-propeller 7, the micro-propeller includes an igniter 8, a propellant chamber 9, a propellant 10, and a nozzle 11. figure 1 Is the composition schematic diagram of this embodiment.

[0031]The working process of this embodiment is: after the drug-releasing microelectronic capsule is swallowed and enters the digestive tract, the control circuit 3 in the drug-releasing microelectronic capsule receives a remote control signal from the outside, or the control circuit 3 itself generates a control signal , the igniter 8 and the power supply mechanism 2 are connected, the igniter 8 ignites the propellant 10, the propellant 10 is ignited to ...

Embodiment 2

[0036] The main structure of this embodiment is the same as that of Embodiment 1, except that the drug-releasing microelectronic capsule in this embodiment includes a sliding protective cover 21, and the sliding protective cover 21 includes 2-5 different diameters. Cylinder 22, propulsion plate 23, rear support plate 24, when sliding protective cover 21 is in shrinkage state, the cylinder cover with big diameter is outside the little cylinder of diameter, and one end of cylinder has inward inward convex edge, in addition One end has an outward outward flange, adjacent two cylinders, the inner diameter of the inner flange of the larger diameter cylinder is smaller than the outer diameter of the outward flange of the smaller diameter cylinder, and the sliding protective cover 21 is in a stretched state , when the cylinder with a large diameter slides to the end, the inward convex edge of the cylinder and the outward convex edge of the cylinder located therein form a barrier, each...

Embodiment 3

[0042] The main structure of this embodiment is the same as that of Embodiment 1, except that the drug-releasing microelectronic capsule in this embodiment includes an elastic bellows 25, and one end of the bellows 25 facing the piston 4 is fixedly connected with a pusher plate 23, One end of the bellows 25 towards the control circuit 3 is fixedly connected with a rear support plate 24, the bellows 25, the pusher plate 23, and the rear support plate 24 form an airtight compartment, and the micro propeller 7 is packaged in the airtight compartment, and the micro propeller 7 The circuit wire passes through the back support plate 24 and is connected with the control circuit 3 . In this embodiment, the bellows 23 can be made of laminated thin metal sheets, or a polymer whose inner wall is coated with a refractory material.

[0043] The main purpose of the bellows 23 is to seal the micro-propeller 7 in it, which can play a moisture-proof role. In addition, the thermal expansion gas...

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Abstract

The drug-releasing microelectronic capsule, in particular, relates to a device for releasing drugs into the digestive tract, which is used to remotely and slowly release substances, such as drugs, food, markers, etc., in the digestive tract of animals or humans. The drug-releasing microelectronic capsule of the present invention includes a housing, a power supply mechanism, a control circuit, a driving mechanism, a piston, and a drug release channel mechanism, and the driving mechanism of the drug-releasing microelectronic capsule includes a micro-propeller, which includes an igniter, After the propellant chamber, nozzle, propellant, and the control circuit of the drug-releasing microelectronic capsule send out the drug-releasing signal, the igniter and the power supply circuit are connected, and the igniter ignites the propellant. After the propellant is ignited, gas and heat are generated, and the expanded gas flows from the The nozzle ejects, and the resulting propelling force is applied to the piston, which moves forward and opens the drug release channel mechanism to release the drug. The invention can effectively overcome negative air pressure, has high reliability, simple structure and is easy to manufacture in batches.

Description

Technical field: [0001] The invention relates to a medicine-releasing microelectronic capsule, in particular to a device for releasing medicine into the digestive tract, which is used for remote release of substances, such as medicine, food, markers, etc., in the digestive tract of animals or human bodies. Background technique: [0002] Electronic capsule is a drug release system based on micro-mechanical electronic technology. It can control the release time and location of drugs in the digestive tract through remote control outside the body. It has good application value in clinical treatment and drug absorption research in the digestive tract. In Chinese patents CN200410040809.3 and ZL02128141.6, the scheme of remote control electronic capsule is disclosed. In the current technical scheme, there is a piston between the drug storage bin, the driving mechanism and the circuit, and the piston has good sealing performance to ensure The liquid medicine does not enter the contr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M31/00A61D7/00A61B5/06A61K9/48A61K9/52
Inventor 皮喜田刘洪英周承文郑小林彭承琳肖霄郑文浩师小荃杨丽丽
Owner CHONGQING UNIV